Christopher Reeve Quotes

With the life expectancy of average Americans heading as high as 85 to 90 years, it is our responsibility to do everything possible to protect the quality of life of the present and future generations. A critical factor will be what we do with human embryonic stem cells. These cells have the potential to cure diseases and conditions ranging from Parkinson's and multiple sclerosis to diabetes and heart disease, Alzheimer's, Lou Gehrig's disease, even spinal-cord injuries like my own. They have been called the body's self-repair kit. Their extraordinary potential is a recent discovery. And much basic research needs to be done before they can be sent to the front lines in the battle against disease. But no obstacle should stand in the way of responsible investigation of their possibilities. To that end, the work should be funded and supervised by the Federal Government through the National Institutes of Health (NIH). That will avoid abuses by for-profit corporations, avoid secrecy and destructive competition between laboratories and ensure the widest possible dissemination of scientific breakthroughs. Human trials should be conducted either on the NIH campus or in carefully monitored clinical facilities. Fortunately, stem cells are readily available and easily harvested. In fertility clinics, women are given a choice of what to do with unused fertilized embryos: they can be discarded, donated to research or frozen for future use. Under NIH supervision, scientists should be allowed to take cells only from women who freely consent to their use for research. This process would not be open ended; within one to two years a sufficient number could be gathered and made available to investigators. For those reasons, the ban on federally funded human embryonic stem cell research should be lifted as quickly as possible. But why has the use of discarded embryos for research suddenly become such an issue? Is it more ethical for a woman to donate unused embryos that will never become human beings, or to let them be tossed away as so much garbage when they could help save thousands of lives?

I've always been a practical person, not one to waste time pursuing unrealistic goals or dreams. But today's dreams can soon become tomorrow's reality in biomedical research. Scientists studying how the brain's cells and chemicals develop, interact, and communicate with the rest of the body have been making strides in alleviating the suffering of patients with Alzheimer's, strokes, Parkinson's, and MS, as well as brain and spinal cord injuries. Only recently researchers have dis-covered that stem cells, which have the ability to adapt to any environmentt in the body, will probably be the most important factor in curing all of these conditions. For example, in order to repair the damaged spinal cord, stem cells can be extracted from the ventricles of the brain or from bone marrow and genetically engineered to become nerve tissue. Highly successful experiments on mice have shown that when these transformed stem cells are transferred into the site of the injury, they apparently understand that their mission is to replace the damaged circuitry, which causes significant functional recovery. Mice that have had their spinal cords completely transected have been able to walk confidently across tightropes and climb rope ladders after this treatment. You would think that these breakthroughs would be a cause for celebration throughout the disabled community. In scientific terms, we are very close to achieving the impossible; in practical terms, we have a long way to go. But it is very disheartening to hear a leading researcher announce, "give us a hundred million dollars and we can cure Parkinson's"; or, "if we raise 300 million dollars, we can find a cure for paralysis in 5 years instead of 15." The idea of spending 15 more years in a wheelchair being fed, dressed, and washed by others would be tolerable if the scientists were still in the dark and there was no hope of recovery. I think most disabled people would agree with me that it is very difficult to cope psychologically with the stark reality that our future now depends mostly on money.

I need to object, and that is that, Senator, you insist on separating therapeutic cloning and embryonic stem cells. However, in my own case, I require re-myelination of nerves. That means replacing the conductive coat of fat, myelin, that allows electricity to come down, currents from the brain to the central nervous system for function. At the moment, only embryonic stem cells have the potential to do that, and experiments are being done now in larger animals demonstrating that.

Even though I don't personally believe in the Lord, I try to behave as though He was watching.

I'm starting a new chapter in my life, and you have no idea how much that means.

We live in a time when the words impossible and unsolvable are no longer part of the scientific community's vocabulary. Each day we move closer to trials that will not just minimize the symptoms of disease and injury but eliminate them.

In the early '80s, the public discourse about AIDS was divisive and ugly. Some elected officials said the disease was God's revenge on people who lived a certain lifestyle. The federal government wouldn't fund research for a cure. But, today, the NIH spends $1.8 billion on AIDS research annually, and the virus is no longer an epidemic in this country. So, how did we get from that climate of fear and animosity in the early '80s to where we are today? Well, it's by the extraordinary efforts of ordinary individuals, then change occurred, as it has time and time again throughout our history.

Superman is nothing more than a popular retelling of the Christ story, or Greek mythology. It's an archetype, watered down and made in vivid colors for twelve-year-old's mentality. It's pop mythology, which extends to the actor, then seeps over to a demand that that actor reflect the needs of the worshipers. The worship doesn't only go on in the temples — it goes on in the streets, and restaurants, in magazines. But, you know, I'm from New Jersey, I'm not from Olympus or Krypton, so back off 'cause I can't take the responsibility.

[N]ever in the history of science have we been given such a gift of being able to use cells that can become any tissue or cell type in the body for the purpose of healing. I think that if you do not have the combination of therapeutic cloning and embryonic stem cells, you are going to be condemning a lot of people to unnecessary and death. If I look around at what else is going on, for years just in the spinal cord community, there has been research on growth factors and Schwann cells, and there have been efforts to stop protein inhibitor, but they have not yet shown the same promise that the embryonic stem cells do, and at the moment, in two places, Washington University in St. Louis and the University of California at Irvine, researchers have been conducting very successful experiments using human embryonic stem cells in animal models in both the acute and chronic phases and getting recovery. Of course, they are going to have to move to the higher animal forms before humans, but the promise is absolutely extraordinary, and I cannot think of any other kind of therapy that would be as effective and as promising as this is. And when I read articles or hear people say that the promise of human embryonic stem cells is dubious, I am very disturbed, because the only reason they get to say that is because the NIH has not been allowed to spend a single dollar on embryonic stem cell research. They have a budget now of $25 billion, and yet, because of lack of guidelines and because of the restrictions that have been imposed on the NIH so far, not one human embryonic stem cell project has been federally funded. That is why you are seeing such slow progress. And if we continue that way, I am going to be in this wheelchair for a long time that I do not need to be, and others like me.

Today, human trials to defeat Parkinson's are underway in Sweden. In Israel, macrophages, scavenger cells that eat debris in the body, are being used to repair the damaged spinal cord within 2 weeks of injury. The first human subject was a 19-year-old girl from Colorado. Last week, the House of Lords in the United Kingdom passed legislation permitting research on cloned human embryos for the second time. Those are not rogue nations behaving irresponsibly. They are allies, no less moral than we are.

Sitting in a chair for more than 4 years now has given me plenty of time to think about many of the distorted and irrational values in our society. For example, all the researchers now agree that the damaged spinal cord can and will be repaired. But, they caution, recovery will only benefit the fittest. This means that the patient must exercise diligently to prevent muscle atrophy, and the loss of bone density and cardiovascular capacity. Special equipment ranging from electrodes that stimulate muscle groups, tilt tables that allow people to stand and bear weight, exercise bicycles, and treadmill therapy, which enables even a quadriplegic to walk while suspended in a harness, are all available. When the cure comes and signals from the brain once again reach the body, individuals who have kept in shape will be able to be rehabilitated relatively quickly and will no longer need payments from their insurance company. But no company will pay for this proactive therapy which would save them hundreds of thousands of dollars in the long run. So most spinal cord injury victims simply deteriorate while they continue to fight for basic quality of life coverage. Meanwhile, the CEOs of many insurance companies are making salaries in the neighborhood of 300 million dollars a year. How much profit is reasonable and justifiable? The same distortion of values is evident in entertainment, sports, and politics. Why do studios pay some of their biggest stars 20 million dollars a picture? Does even the most gifted athlete deserve 91 million dollars over 7 years to swing a bat and catch a baseball? Why is it that so many of our elected officials end up in office primarily because they have been able to outspend their opponents? At the other end of the spectrum, why has the NIH since its inception in 1940 had to plead incessantly for enough money to battle every disease in the encyclopedia?

A hero is an ordinary person doing things in an extra ordinary way.

If you believe in the slippery slope here, it means that our entire society is perched on the slippery slope. It means that regulation has no value whatsoever, and that is not true. Now, there are always consequences. We allow 16-year-olds to get driver's licenses, and a lot of them have accidents - but do we rescind the permission to drive a car at 16? No.

Now fortunately, even a couple of years before my injury, we were in the dark ages about spinal cord and the common wisdom was that the cord could not regenerate. But I want to say that one of the great heros and really the father of regeneration is a distinguished Canadian who will go down in history as the father of spinal cord recovery. And that is Professor Alberto Aguierro at McGill University. He is the one who discovered that there are two protein molecules at the base of the brain stem. The positive function of these molecules is to stop the brain from overdeveloping during gestation. But then in the adult these protein molecules perform a negative function, they stop the regeneration of nerves in the spinal cord. Now you can chop off your hand then a surgeon can sew it back on again and you can go out and throw a baseball, because of the plasticity and ease with which the peripheral nervous system is able to make appropriate connections. And the good news now for us is that they have discovered nerves regenerate in the spinal cord they seek to find appropriate connections across the injury, across the lesion. And when these appropriate connections are made there will be improvement in sensation and in motor function and depending on the severity of the injury, there are endless possibilities to how much recovery can occur. If someone has been very damaged there may be limitations, if someone is less damaged there may be a better outcome. But the point is, through regeneration the use of human embryonic cells, the use of gene therapy, the spinal cord can and will regenerate and so it is only a question of time before these techniques make their way into humans. One of the most exciting discoveries was made by a Dr. Viscovi in Milan who found that there are cells called epitomal cells which were thought to only exist in again, in the child during gestation, because these cells are undifferentiated and they can become anything. Well, very recently, just two months ago these cells were found to exist in the adult in the ventricles of the brain, in the spinal cord and even in the skin. And this is tremendously exciting because the hope, the best hope for recovery now, is to biopsy these cells from your skin, from your hand for example, they could grow hundreds of thousands of cells in a petri dish and genetically instruct them to become neurons and axons. They would then be injected inside of the injury and they would become the nerves necessary to carry messages from the brain to the rest of the body. Now that would have been science fiction a few years ago, but it's here and it's happening and it doesn't matter whether it's an acute injury or a chronic injury. So I offer you the specific detail, not to give you a boring science lecture but to tell you there is very real tangible hope, very real hope...And one of the great advantages of this technique is that there is no danger of toxicity to the body or rejection by the immune system. And what I love about it is the body is healing itself. Taking cells from one part and using them in another area and I think that's some-how a beautiful design, rather than loading up the body with more chemicals and more drugs and more artificial agents.

The insurance companies see this legislation as a tax. My question is: why is that unreasonable, particularly when the insurance companies would save so much money in the long run. Research will keep the American people healthier, resulting in fewer insurance claims. We tax oil companies and use the money to build and maintain highways. In New York state, if you win the lottery, you pay a significant tax which goes to a state fund for education. Most states have sales taxes which are a major source of revenue for a wide variety of programs and services that benefit the public. Why shouldn't insurance companies be asked to help solve the health care crisis in this country? Because of the advances to date, we can save millions of lives. Our challenge for the future is not just improving the quality of life of those we save, but finding the cures to prevent that suf-fering in the first place. Our scientists are on the threshold of major breakthroughs in almost every disease or condition that now cause so much hardship for people across the country and around the world. The insurance companies owe it to our families and our society to make a small sacrifice which can do so much good. I hope that this excellent piece of legislation which already has tremendous grassroots support will be enacted during this legislative session.