We do not yet adequately understand the way in which the different environments in the world have selected over time the genes which determine our capacity to do different things. The overwhelming desire of society today is to assume that equal powers of reason are a universal heritage of humanity. It may well be. But simply wanting this to be the case is not enough. This is not science. To question this is not to give in to racism. This is not a discussion about superiority or inferiority, it is about seeking to understand differences, about why some of us are great musicians and others great engineers. It is very likely that at least some 10 to 15 years will pass before we get an adequate understanding for the relative importance of nature versus nurture in the achievement of important human objectives. Until then, we as scientists, wherever we wish to place ourselves in this great debate, should take care in claiming what are unarguable truths without the support of evidence.

Right now, at my institute in the US we are working on gene-caused failures in brain development that frequently lead to autism and schizophrenia. We may also find that differences in these respective brain development genes also lead to differences in our abilities to carry out different mental tasks. In some cases, how these genes function may help us to understand variations in IQ, or why some people excel at poetry but are terrible at mathematics. All too often people with high mathematical abilities have autistic traits. The same gene that gives some people such great mathematical abilities may also lead to autistic behaviour. This is why, in studying autism and schizophrenia, we believe that we shall come very close to a better understanding of intelligence and, therefore, of the differences in intelligence.

The thought that some people are innately wicked disturbs me. But science is not here to make us feel good. It is to answer questions in the service of knowledge and greater understanding. In finding out the extent to which genes influence moral behaviour, we shall also be able to understand how genes influence intellectual capacities.

Since 1978, when a pail of water was dumped over my Harvard friend E. O. Wilson for saying that genes influence human behaviour, the assault against human behavioural genetics by wishful thinking has remained vigorous. But irrationality must soon recede. It will soon be possible to read individual genetic messages at costs which will not bankrupt our health systems. In so doing, I hope we see whether changes in DNA sequence, not environmental influences, result in behaviour differences. Finally, we should be able to establish the relative importance of nature as opposed to nurture.

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Science is no stranger to controversy. The pursuit of discovery, of knowledge, is often uncomfortable and disconcerting. I have never been one to shy away from stating what I believe to be the truth, however difficult it might prove to be. This has, at times, got me in hot water. Rarely more so than right now, where I find myself at the centre of a storm of criticism. I can understand much of this reaction. For if I said what I was quoted as saying, then I can only admit that I am bewildered by it. To those who have drawn the inference from my words that Africa, as a continent, is somehow genetically inferior, I can only apologise unreservedly. That is not what I meant. More importantly from my point of view, there is no scientific basis for such a belief. I have always fiercely defended the position that we should base our view of the world on the state of our knowledge, on fact, and not on what we would like it to be. This is why genetics is so important. For it will lead us to answers to many of the big and difficult questions that have troubled people for hundreds, if not thousands, of years. But those answers may not be easy, for, as I know all too well, genetics can be cruel. My own son may be one of its victims. Warm and perceptive at the age of 37, Rufus cannot lead an independent life because of schizophrenia, lacking the ability to engage in day-to-day activities.

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For all my life, America was the place to be. And we somehow continue to be the place where there are real opportunities to change the world for the better. I'm basically a libertarian. I don't want to restrict anyone from doing anything unless it's going to harm me. I don't want to pass a law stopping someone from smoking. It's just too dangerous. You lose the concept of a free society. Since we are genetically so diverse and our brains are so different, we're going to have different aspirations. The things that will satisfy me won't satisfy you. On the other hand, if global warming is in any way preventable and it's likely to come, not doing something would be irresponsible to the future of our society.

Science Ph.D. students have effectively become serfs. And who would become a serf when you can work for Goldman Sachs and get paid $300,000 a year to become a serf? Why drive a Chevy when you can drive a BMW — and now you're condemned to driving a car from Malaysia or something. Life should be fun.