"For most people, the central questions of existence ultimately come down to transcendental ones: Why is there a universe at all? Why are we here?
Whatever presumptions one might bring to the question "Why?," if we understand the "how" better, "why" will come into sharper focus."

People say to me, “Are you looking for the ultimate laws of physics?” No, I’m not. I’m just looking to find out more about the world, and if it turns out there is a simple ultimate law that explains everything, so be it. That would be very nice to discover. If it turns out it’s like an onion with millions of layers, and we’re sick and tired of looking at layers, then that’s the way it is . . . My interest in science is to simply find out more about the world, and the more I find out, the better it is. I like to find out.

But when you look at CMB map, you also see that the structure that is observed, is in fact, in a weird way, correlated with the plane of the earth around the sun. Is this Copernicus coming back to haunt us? That's crazy. We're looking out at the whole universe. There's no way there should be a correlation of structure with our motion of the earth around the sun - the plane of the earth around the sun - the ecliptic. That would say we are truly the center of the universe. The new results are either telling us that all of science is wrong and we're the center of the universe, or maybe the data is (s)imply incorrect, or maybe it's telling us there's something weird about the microwave background results and that maybe, maybe there's something wrong with our theories on the larger scales.

I've told you two things : First, you're much more insignificant than you ever imagined and second, the future is miserable. But you should be happy, because we may live in a universe without purpose but that means the purpose in our lives is the purpose we create. And we should consider ourselves fortunate to have evolved in this place in the middle of nowhere and evolved a consciousness so we can understand the universe from the earliest moments of the big bang to the far future. So instead of being depressed, you should enjoy your brief moment in the sun.

"[...] It is. Philosophy is a field that, unfortunately, reminds me of that old Woody Allen joke, "those that can't do, teach, and those that can't teach, teach gym." And the worst part of philosophy is the philosophy of science; the only people, as far as I can tell, that read work by philosophers of science are other philosophers of science. It has no impact on physics what so ever, and I doubt that other philosophers read it because it's fairly technical. And so it's really hard to understand what justifies it. And so I'd say that this tension occurs because people in philosophy feel threatened, and they have every right to feel threatened, because science progresses and philosophy doesn't.
[the atlantic, Has Physics Made Philosophy and Religion Obsolete? - interview, apr 23 2012]"

Science has been effective at furthering our understanding of nature because the scientific ethos is based on three key principles: (1) follow the evidence wherever it leads; (2) if one has a theory, one needs to be willing to try to prove it wrong as much as one tries to prove that it is right; (3) the ultimate arbiter of truth is experiment, not the comfort one derives from one's a priori beliefs, nor the beauty or elegance one ascribes to one's theoretical models.

"The date here is very interesting, because, as far as I can determine, the first Star Trek episode to refer to a black hole, which it called a "black star," was aired in 1967 before Wheeler ever used the term in public."