I've had long and sometimes difficult discussions, especially about the singularity of the origin of Eukaryotes... A lot of people don't like that. ...[I]t's not really about what does it say about the probability of life elsewhere, although it has things to say to that. It's really about life on earth, and a lot of people are very uncomfortable with the idea of improbability... I've had quite difficult discussions with some students about that, but rarely... about life elsewhere in the Universe.

Thew problem here for me is that I'm in a biology department and is still somewhat frowned upon by a lot of biologists who would see it as a form of speculation. So the courses that I teach are about life on earth and they're not so much about life in the Universe... [I]t is something that I should develop, I think.

[M]ost of what I teach and interact with the students is more about life on earth and the principles governing evolution, and from my own point of view, the biochemical side, which is not normally part of the evolutionary biology... [I]t's relatively rare for me to discuss life elsewhere in the Universe with them.

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Does anyone care if there's an awful waste of space? It's a form of wishful thinking... We would love for the Universe to be full. ...Personally, I grew up on the Hichiker's Guide to the Universe, those kind of crazy science fiction yarns, or Star Wars or whatever it may be. The idea that the Universe is full of other intelligent beings, all kind of finding a way of getting along or having a war, but having some heroism thrown in, but... it's all human vision of ourselves thrown onto a cosmic scale. Do I believe any of it? No... Is there anything that I think, from my understanding as a biologist, that would tend to lead to that? No... Does it matter if it's a tremendous waste of space? Well, that's to say "What's the point of the Big Bang?" I don't know. The idea that the Universe may be completely empty apart from matter and energy? It would seem to be, perhaps, the default hypothesis. The fact that we find life is surprising. It would be nice if there were laws of the Universe that tended to give rise to life. Maybe there are at the level of bacteria. I don't see it at the level of large, morphologically complex beings... I think it's emotive. It's pleasing, but I doubt it's true.

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I do like this quote from Simon Conway Morris that if the aliens call then don't pick up the phone. I'm not sure I'd really like to meet any of them very much. Perhaps... meeting bacteria would be the least scary... [T]he chances of meeting aliens is so remote that I haven't really troubled myself very much about it. It would be nice to think that if we did, somehow they would be a superior intelligence... they would have solved a lot of the problems of aggression and whatever else that humans have, but I fear not. I fear that it would be the opposite, that... natural selection has a knack of producing nastiness in intelligence.

[On the controversy between and .] [T]he classic case of convergence would be the eye and the human eye, or ian eyes. ...The common ancestor they had had a light sensitive spot, they did have some regulatory genes in common... for example, but that had to effectively independently recruit all the rest of the genes required to make a camera type eye, and that direction of evolutionary travel was in parallel. It was convergent. We even see in some s... a camera-type eye in single-celled critters where there's a retina made from s. There's a made from mitochondria. There's a there. They don't have a brain. I don't know how they use this thing but... plainly it's a camera-type eye. ...It's a of some sort. ...I would see that as a completely independent origin of a camera-type eye, albeit without a brain. I would see the octopus' and mammalian eye as being convergence in the Simon Conway Morris sense... There are certain ways that you can make an eye, that work, and all the steps along the way have to be favored, and... perhaps there are seven or eight... fundamentally different types of eye that we see on earth, and most of them have arisen more than once, always from a common ancestor, generally, that had as a light sensitive pigment. So you're then into an interesting terrain or... How common are the right types of light sensitive pigment? They're chemically not so straight forward.

It requires that life elsewhere should be modeled along similar lines to life here, which is that it should be cellular, it should be carbon-based. It should be in water. If those things are not true, then there's no reason why that numbers game would apply anywhere else. But if those things are true, then yes, I think the fact that photosynthesis only arose once, that Eucaryotes only arose once, that what Nick [Nicholas J.] Butterfield calls organ grade multicellularity, which is to say quite serious differentiation with scores of different cell types and specializations. We don't see that in fungi. We don't see that in algae. ...[Y]ou see two or three different types of cell. So that's rare. It's in plants and it's in animals. It begins to look less likely. I think it's reasonable to say it's less likely, but I wouldn't like to rely too much or put too much weight on it.

<nowiki>[</nowiki>Martin Rees] may be right. If we were to go back 5 million years, as intelligent apes, and ask ourselves "What is postbiological life?" I think the answer is it's not a concept that would possibly mean anything. So we've had... 4 billion years of life on earth, and it's come up with an enormous wealth and variation, but it's all organic and... the chances of it coming up with humans? I can't put a number on that. ...I don't think there's an inevitability that life, once it's started will give rise to a human-like intelligence or beyond that. I think there's nothing inevitable about it, and if we just go back a few million years on earth, there was nothing inevitable about it. So I, personally would still look for organic life, but... I'm not sure that would be the easiest thing to find. It may be that it's easier to find, yes, nano aliens or something.

I like philosophers. I think they can teach scientists how to think very often, and... there's a lot of sloppy thinking among scientists, and I think philosophers can be quite rigorous about it. It gets a lot of scientists cross with philosophers who don't engage with science, but I think there are more philosophers these days who are engaging in a serious way with science. I think they have important things to say.

I've been asked on various occasions, "Why don't we, as an origins of life community, get together, think what a killer experiment is, and then go and build a or something, where we go and do the experiment?" And the answer to that is... [W]e can't agree with each other about what experiment would you do? ...[I]t is intrinsically a lot more complex, precisely because it's a continuum. We don't know. We don't agree about what environment, we don't agree about what kind of chemistry or biochemistry. We can't join these things up, and so it seems to me a much healthier environment is to be deliberately multiple about it. Not to say, "Ok, this particular world view is going to dominate." I think we have to have multiple views until we know more.

That's why they [viruses] are not in the tree of life. They don't relate in a very direct way. ...[T]he tree of life now is not only about ribosomes. You can build trees from whole genomes, but viral genomes? They don't really fit in, in a way which makes sense to people.

[I]t's interesting to me that the bacteriophages, the viruses that you find in bacteria, are not remotely similar to the ones that you find infecting archaea, which again are not remotely similar to eukaryotic viruses. ...They're different in their appearance. They're different in their mechanisms in which they force their... I mean the bacteriophages are these classic lunar module landing things... They are stunning things to look at. ...Some es look like bottle balls or postage stamps, strange shapes... They don't have any genes in common. They don't have mechanisms of entry into cells in common. They appear to be independently derived.

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I think there's plenty of solutions to Fermi's paradox, that we don't need to add this as an extra one, but yes, this would be my favorite explanation for it, that there is no inevitability about complex life, that there's nothing in the laws of cosmology that say, "[Complex] Life will start." I think that there probably is something in the laws of cosmology lending itself towards bacteria, but the idea of more complex life... I certainly wouldn't see a Simon Conway Morris view, for example, that the origin of life is so complex that you require God to put everything in motion and then will take you all the way to humans.