The inner logic of ... Much of it is imposed by thermodynamics; some is facilitated by catalysts. Some is refined by genes. And part stems from the vicissitudes of life itself, which forced evolution down improbable paths, while transforming our geologically restless globe from a sterile, anoxic planet into the living, high-octane world of today.

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The double helix of DNA... is composed of two long chains [of 'letters'] that snake around each other... each strand providing an exact template for the other. ...[E]ach strand ...contains just four types of letter, with ...billions ...arranged down... the chain. ...3,000 million letters ...make up the human genome ...[T]he same — the same lines of code — can have different effects depending on the context.

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Even the laws of thermodynamics... can be recast in terms of information — Shannon entropy, the laws of bits of information. But this view generates its own paradox at the origin of life. ...Place information at the heart of life, and there is a problem with the emergence of function ...the origin of biological information. There are problems... in understanding why we age and die... diseases... and how experiences can give rise to conscious mind. ...A far better question ...what processes animate cells and set them apart from inanimate matter?

For decades, biology has been dominated by information—the power of genes. ...[Y]et there is no difference in the information content of a living protozoon and one that died ...The difference between alive and dead lies in energy flow ...the ability of cells to continually regenerate themselves from simpler building blocks.

I see myself as a biologist or a biochemist, but... in the context of as a broader subject, it forces me to wrestle with physics, with cosmology, with chemistry, with geology, with earth sciences or planetary sciences, and that's a thrill. ...I think it's what most people are drawn into science in the first place for, because science, in its biggest sense, is what inspires people, and by the time that you've got to the level of doing a PhD, it's narrowed down so much that a lot of people are almost forced to lose their imagination, and their creativity as a scientist... I think astrobiology is a subject that puts all that back in, in heaps.