If every trace of any single religion were wiped out and nothing were passed on, it would never be created exactly that way again. There might be some other nonsense in its place, but not that exact nonsense. If all of science were wiped out, it would still be true and someone would find a way to figure it all out again.

It's not arrogant to say that you can't figure out the answers to the universe with your internal faith. It's not arrogant to know that there's no omniscient, omnipotent prime mover in the universe who loves you personally. It's not sad to feel that life and the love of your real friends and family is more than enough to make life worth living. Isn't it much sadder to feel that there is a more important love required than the love of the people who have chosen to spend their limited time with you?

Nobody that has seen a baby born can believe in god for a second. When you see your child born, and the panic, and the amount of technology that is saving the life of the two people you love most in the world, when you see how much stainless steel and money it takes to fight off the fact that god wants both those people dead, no one, no one can look into the eyes of a newborn baby and say there's a god, because I'll tell ya, if we were squatting in the woods, the two people I love most would be dead. There's just no way around that. If I were in charge, no way. We need technology to fight against nature; nature so wants us dead. Nature is trying to kill us.

Every time something really bad happens, people cry out for safety, and the government answers by taking rights away from good people. We have no proof that the bad, stupid crazy people who have planted bombs in the past few years used the phone much for their stupid bad crimes, let alone logged on the Internet. Yet when those kind of bad things happen nowadays, the government tries to do bad things to phones and the Net. The phones and the Internet are just good smart things, and the government should leave them alone. You have to watch the government all the time on everything. Thomas Jefferson didn't say that, but he said something very close to that.

Interviewer: Are there any groups you won’t go after? Penn: We haven’t tackled Scientology [in Penn & Teller: Bullshit!] because Showtime doesn’t want us to. Maybe they have deals with individual Scientologists—I’m not sure. And we haven’t tackled Islam because we have families.
Interviewer: Meaning, you won’t attack Islam because you’re afraid it’ll attack back … Penn: Right, and I think the worst thing you can say about a group in a free society is that you’re afraid to talk about it—I can’t think of anything more horrific.

I very much enjoy stating that I have never had a drink of alcohol or a toke of any recreational drug in my life. What I don’t state is that I will never have a drink of alcohol or a toke of any recreational drug in my life. I can report on the past, but I’m reluctant to predict the future. The hippies were right about fresh vegetables and staying away from fast food, so maybe they’re right about LSD. What the fuck do I know? I don’t even trust myself completely on the past. I remember things wrong all the time. I’m not willing to say I’m never going to do recreational heroin, so I’m sure as shooting not going to close the Big Mac door forever.

Rabbi Daniel Lapin: Here's a really blunt question: would the world be a better or a worse place if a billion Muslims became evangelical Christians tomorrow?
Penn: [long pause] Everything else being equal, I think "yes". Rabbi Daniel Lapin: Then we agree.
Penn: The argument is made by me that the celebration of faith, the glorification of faith, and faith being defined as The Bible kind of does as belief without proof, is not something that I feel is good to celebrate. To answer the question about evil, I always find that evil takes responsibility away. I want to have—whether it’s me or whether it's a criminal—I want to have full responsibility of my mistakes. And I think when you have this image, whether it's the Disney image of devil Pluto and angel Pluto on your shoulders, pulling you one direction or another, I think that idea of evil is an idea that is anti-responsibility.