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" "Despite the evidence that ventricular hormones do not make their way out of the ventricle, the presence of large ventricles in many schizophrenic patients, and the ability of two-dimensional gels to provide a profile of peptides in the ventricle, not a single catheter has been placed into the ventricle of a schizophrenic patient to measure the peptides in the ventricle. ...There is no animal model for this disease, the answer can only come from human studies.
Richard M. Bergland (1932 - 2007) was an author, administrator, neurosurgeon and neuroscientist. He was chief of neurosurgery at Beth Israel Hospital of New York. He was also a Van Wagenen Scholar, a Markle Scholar and Macy Faculty Scholar and served academic appointments at Oxford, Harvard, Cornell and Columbia, among others.
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The science of neuroendocrinology—the brain-to-pituitary link that was discerned by [Joe] Hinsey, [George] Wislocki, du Vigneaud, and [Geoffrey] Harris—is dependent upon hormones flowing within nerve axons. This phenomenon, axonal flow, was first noted by Ernst and Barta Scharrer... For many decades it was assumed that axonal flow was always 'down'... away from the brain.
It would be easier... if all animals spoke the same endocrine language, for then correlations made in the laboratory could be quickly moved to the bedside. Unfortunately, such is not the case. The hormone prolactin, for example, has at least seventy-eight different functions in seventy-eight different species
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The belief that electricity, the fourth of the modern forces, is the stuff of thought has permeated brain science since the late 1700s. ...while the brain was regarded as 'dry', all other organs were conceived as 'wet'. Doubtless the study of brain electricity helped in understanding the internal circuits of the brain, but it solved few problems of brain disease.