For your book to be read in 20y, make sure content is 1) important for people today, 2) was also important 20 y ago. - Nassim Nicholas Taleb

Statin drugs are meant to lower cholesterol in your blood. But there is an asymmetry, and a severe one. One needs to treat fifty high risk persons for five years to avoid a single cardiovascular event. Statins can potentially harm people who are not very sick, for whom the benefits are either minimal or totally nonexistent.

The casino is the only human venture I know where the probabilities are known, Gaussian (i.e., bell-curve), and almost computable.

Never ask your client for advice.