Up to 1868, nearly four hundred treaties had been signed by the United States government with various Indian groups, and scarcely a one had remained … - Peter Farb

The desire of Whites to occupy Indian lands, and the constant rivalry between French and English traders for furs gathered by the Indians, led to many skirmishes and several bloody wars, all of which involved Indians on both sides. The Whites were determined to fight it out with each other—down to the last Indian. These battles culminated in the French and Indian War of 1763, which represented a disaster to many Indian groups in the northeastern part of the continent. In May, 1763, an Ottawa warrior by the name of Pontiac fell upon Detroit and captured the English forts, one after the other. Lord Jeffery Amherst... distributed among the Indians handkerchiefs and blankets from the small pox hospital at Fort Pitt—probably the first use of biological warfare in history.

Before the passage of the Removal Act of 1830, a group of Cherokee chiefs went to the Senate committee that was studying this legislation to report on what they had already achieved... They expressed the hope that they would be permitted to enjoy in peace "the blessings of civilization and Christianity on the soil of their rightful inheritance." Instead they were... denied even the basic protection of the federal government. The Removal Act was carried out almost everywhere with total lack of compassion, but in the case of the Cherokee—civilized and Christianized as they were—it was particularly brutal.

After the Spaniards settled the Southwest, the Navajo began another burst of cultural borrowing—or, more actually, stealing. Spanish ranches and villages were so depleted of horses—not to mention sheep—that by 1775 the Spaniards had to send to Europe for 1,500 additional horses. After the Pueblo Rebellion against the Spaniards was put down in 1692, many Pueblo took refuge with their Navajo neighbors—and taught them how to weave blankets, a skill for which the Navajo are still noted, and to make pottery. During this time the Navajo probably absorbed many Pueblo religious and social ideas and customs as well, such as ceremonial paraphernalia and possibly the Pueblo class system.