I had now reached that phase of the disorder where all sense of hope had vanished, along with the idea of a futurity; my brain, in thrall to its outl… - William Styron

When At Play in the Fields of the Lord was published in 1965 there was revealed in stunning outline the fully realized work of a novelist writing at white heat and at the peak of his powers; [...] Peter is a poet and a scientist, and the mingling of these two personae has given us such carefully observed, unsentimental, yet lyrically echoing works as The Cloud Forest, Under the Mountain Wall, The Tree where Man was Born and The Snow Leopard. [...] We behold a writer of phenomenal scope and versatility.

In many of Albrecht Dürer’s engravings there are harrowing depictions of his own melancholia; the manic wheeling stars of Van Gogh are the precursors of the artist’s plunge into dementia and the extinction of self. It is a suffering that often tinges the music of Beethoven, of Schumann and Mahler, and permeates the darker cantatas of Bach. The vast metaphor which most faithfully represents this fathomless ordeal, however, is that of Dante, and his all-too-familiar lines still arrest the imagination with their augury of the unknowable, the black struggle to come:

the gray drizzle of horror induced by depression takes on the quality of physical pain. But it is not an immediately identifiable pain, like that of a broken limb. It may be more accurate to say that despair, owing to some evil trick played upon the sick brain by the inhabiting psyche, comes to resemble the diabolical discomfort of being imprisoned in a fiercely overheated room. And because no breeze stirs this caldron, because there is no escape from this smothering confinement, it is entirely natural that the victim begins to think ceaselessly of oblivion.