The value of a college education is not the learning of many facts but the training of the mind to think, he [Einstein] said. - Walter Isaacson

Remembering that you are going to die is the best way I know to avoid the trap of thinking you have something to lose. You are already naked. There is no reason not to follow your heart.

Seek knowledge for its own sake. Not all knowledge needs to be useful. Sometimes it should be pursued for pure pleasure. Leonardo did not need to know how heart valves work to paint the Mona Lisa, nor did he need to figure out how fossils got to the top of mountains to produce Virgin of the Rocks. By allowing himself to be driven by pure curiosity, he got to explore more horizons and see more connections than anyone else of his era.

One mark of a great mind is the willingness to change it. We can see that in Leonardo. As he wrestled with his earth and water studies during the early 1500s, he ran into evidence that caused him to revise his belief in the microcosm-macrocosm analogy. It was Leonardo at his best, and we have the great fortune of being able to watch that evolution as he wrote the Codex Leicester. There he engaged in a dialogue between theories and experience, and when they conflicted he was receptive to trying a new theory. That willingness to surrender preconceptions was key to his creativity.