We have heard that nature can sing some strange and unfamiliar songs. In coming to appreciate these songs, we develop a heightened perception... leav… - Frank Wilczek

In the past scientists have repeatedly reached “intellectual closure” on inadequate pictures of the universe, and underestimated its scale.

Intelligent creatures [that] evolved to live deep within the atmosphere of a gas giant planet could be deluded, for eons, into thinking that the Universe is an approximately homogeneous expanse of gas, filling a three-dimensional space, but featuring anisotropic laws of motion (which we would ascribe to the planet’s gravitational field). Are we human scientists comparably blinkered?

In most theoretical embodiments of inflationary cosmology, the currently observed universe appears as a small part of a much larger multiverse. In this framework to hold throughout the universe need not hold through all space. They can be accidents of our local geography, so to speak. If that is so, then it is valid – indeed, necessary – to consider selection effects. It may be that some of the “fundamental constants”, in particular, cannot be determined by theoretical reasoning, even in principle, because they really are different elsewhere.