For the theory-practice iteration to work, the scientist must be, as it were, mentally ambidextrous; fascinated equally on the one hand by possible m… - George E. P. Box

Essentially, all models are wrong, but some are useful.

I want to tell you how I got to be a statistician. I was, of course, born in England and in 1939... when war broke out in September of that year, although I was close to getting a degree in Chemistry, I abandoned that and joined the Army. They put me in the Engineers (and when I see a bridge I still catch myself calculating where I would put the charges to blow it up). Before I could actually do any of that I was moved to a highly secret experimental station in the south of England. At the time they were bombing London every night and our job was to help to find out what to do if, one night, they used poisonous gas. Some of England's best scientists were there. There were a lot of experiments with small animals, I was a lab assistant making biochemical determinations, my boss was a professor of physiology dressed up as a colonel, and I was dressed up as a staff sergeant. The results I was getting were very variable and I told my colonel that what we really needed was a statistician. He said "we can't get one, what do you know about it?" I said "Nothing, I once tried to read a book about it by someone called R. A. Fisher but I didn't understand it". He said "You've read the book so you better do it", so I said, "Yes sir"

A man in daily muddy contact with field experiments could not be expected to have much faith in any direct assumption of independently distributed normal errors.