If one looks at the special problems that were the mainsprings of progress along the oldest and most persistent lines of human inquiry, then one find… - John Barrow

The physicist's concept of nothing—the vacuum... began as empty space—the void... turned into a stagnant ether through which all the motions of the Universe swam, vanished in Einstein's hands, then re-emerged in the twentieth-century quantum picture of how Nature works.

Scanning the past millennia of human achievement reveals just how much has been achieved during the last three hundred years since Newton set in motion the effective mathematization of Nature. We found that the world is curiously adapted to a simple mathematical description. It is enigma enough that the world is described by mathematics; but by simple mathematics, of the sort that a few years energetic study now produces familiarity with, this is an enigma within an enigma.

Location is not, as the estate agents say, everything. We must also consider our place in history.