Assuming the simulators, or at least the early generations of them, have a very advanced knowledge of the laws of Nature, it's likely that they would… - John Barrow

The abstractions of Einstein's curved space and time gave rise to analogies and pictures that played a new explanatory role. Space and time gave way to space-time, visible light was augmented by images across the rest of the electromagnetic spectrum, and we realised that we could see back towards the apparent beginnings of time.

The physicist's concept of nothing—the vacuum... began as empty space—the void... turned into a stagnant ether through which all the motions of the Universe swam, vanished in Einstein's hands, then re-emerged in the twentieth-century quantum picture of how Nature works.

Each of the most basic physical laws that we know corresponds to some invariance, which in turn is equivalent to a collection of changes which form a symmetry group. ...whilst leaving some underlying theme unchanged. ...for example, the conservation of energy is equivalent to the invariance of the laws of motion with respect to translations backwards or forwards in time... the conservation of linear momentum is equivalent to the invariance of the laws of motion with respect to the position of your laboratory in space, and the conservation of angular momentum to an invariance with respect to directional orientation... discovery of conservation laws indicated that Nature possessed built-in sustaining principles which prevented the world from just ceasing to be. There were fewer roles for the Deity to play...