To have success in science, you need some luck. But to succeed in science, you need a lot more than luck. And it's not enough to be smart — lots of people are very bright and get nowhere in life. In my view, you have to combine intelligence with a willingness not to follow conventions when they block your path forward.

Success in science and scientific work come not through the provision of unlimited or big resources, but in the wise and careful selection of problems and objectives. Above all, what is required is hard sustained work and dedication.

To succeed in science, you have to avoid dumb people (here I was still following Luria's example). Now that might sound inexcusably flip, but the fact is that you must always turn to people who are brighter than yourself.

That is the idea that we all hope you have learned in studying science in school — we never explicitly say what this is, but just hope that you catch on by all the examples of scientific investigation. It is interesting, therefore, to bring it out now and speak of it explicitly. It’s a kind of scientific integrity, a principle of scientific thought that corresponds to a kind of utter honesty — a kind of leaning over backwards.

For example, if you’re doing an experiment, you should report everything that you think might make it invalid — not only what you think is right about it: other causes that could possibly explain your results; and things you thought of that you’ve eliminated by some other experiment, and how they worked — to make sure the other fellow can tell they have been eliminated.
Details that could throw doubt on your interpretation must be given, if you know them. You must do the best you can — if you know anything at all wrong, or possibly wrong — to explain it. If you make a theory, for example, and advertise it, or put it out, then you must also put down all the facts that disagree with it, as well as those that agree with it. There is also a more subtle problem. When you have put a lot of ideas together to make an elaborate theory, you want to make sure, when explaining what it fits, that those things it fits are not just the things that gave you the idea for the theory; but that the finished theory makes something else come out right, in addition.
In summary, the idea is to try to give all of the information to help others to judge the value of your contribution; not just the information that leads to judgment in one particular direction or another.
The first principle is that you must not fool yourself — and you are the easiest person to fool. So you have to be very careful about that. After you’ve not fooled yourself, it’s easy not to fool other scientists...
You just have to be honest in a conventional way after that.

One of the reasons for its success is that science has a built-in, error-correcting machinery at its very heart. Some may consider this an overbroad characterization, but to me every time we exercise self-criticism, every time we test our ideas against the outside world, we are doing science. When we are self-indulgent and uncritical, when we confuse hopes and facts, we slide into pseudoscience and superstition.

One of the reasons for its success is that science has built-in, error-correcting machinery at its very heart. Some may consider this an overbroad characterization, but to me every time we exercise self-criticism, every time we test our ideas against the outside world, we are doing science. When we are self-indulgent and uncritical, when we confuse hopes and facts, we slide into pseudoscience and superstition.

Keep stupid, keep crazy. Knowledge begins with wonder. Success as a scientist is based on keen curiosity. If one wants to enjoy academic life, I would recommend him or her to be different.

To make a huge success, a scientist must be prepared to get into deep trouble. Sometime or another, someone will tell you that you are not ready to do something. … If you are going to make a big jump in science, you will very likely be unqualified to succeed by definition. The truth, however, won't save you from criticism. Your very willingness to take on a very big goal will offend some people who will think that you are too big for your britches and crazy to boot.

One of the characteristics of successful scientists is having courage. Once you get your courage up and believe that you can do important problems, then you can. If you think you can't, almost surely you are not going to. [...] The average scientist, so far as I can make out, spends almost all his time working on problems which he believes will not be important and he also doesn't believe that they will lead to important problems. [...] In summary, I claim that some of the reasons why so many people who have greatness within their grasp don't succeed are: they don't work on important problems, they don't become emotionally involved, they don't try and change what is difficult to some other situation which is easily done but is still important, and they keep giving themselves alibis why they don't.

Not every experiment is a success. That’s the nature of doing science.” The nature of doing many things, I might add: success is its own reward, but failure is a great teacher too, and not to be feared.

One of the most basic things I've tried to do is give people a greater understanding of how science works - the importance of evidence, the importance of many trials, of rigorous studies, and the idea that we learn only a little bit at a time. . . . Making people aware of that process helps increase appreciation and respect for science, and that helps us make informed decisions for our families and ourselves.

You learn as you go, and I think the most important thing to remember is that you are not your failures. That was a hard pill for me to swallow and something I'm still working through but the scientific process is built on failing! We have a theory, we test it, and a lot of the times that theory is wrong. That doesn't mean you aren't smart or you shouldn't continue testing other theories! Scientific exploration would come to a screeching halt if at every failed theory a scientist would quit.

Success will come easier and faster as a young scientist if you are confident about your abilities, are not afraid to step out of your comfort zone, seek out a mentor, and collaborate on projects. This will improve the likelihood of obtaining competitive funding, and increasing research and publication productivity.

How scientists go about their job: and it's a process, it's a question of asking questions, respecting observation, respecting experiment, having tentative explanations and then testing them.... There is a problem sometimes with how we teach science at schools. Because we sometimes teach it as if it has been chiseled in stone.