Relativity does set limits on what humans can ultimately do. But the universe is not required to be in perfect harmony with human aspirations. - Carl Sagan

The universe is not required to be in perfect harmony with human ambition.

Science requires us to be freed of gross superstition and gross injustice both. Often, superstition and injustice are imposed by the same ecclesiastical and secular authorities, working hand in glove. It is no surprise that political revolutions, scepticism about religion, and the rise of science might go together.

In those cultures lacking unfamiliar challenges, external or internal, where fundamental change is unneeded, novel ideas need not be encouraged. Indeed, heresies can be declared dangerous; thinking can be rigidified; and sanctions against impermissible ideas can be enforced — all without much harm. But under varied and changing environmental or biological or political circumstances, simply copying the old ways no longer works. Then, a premium awaits those who, instead of blandly following tradition, or trying to foist their preferences on to the physical or social Universe, are open to what the Universe teaches.

Whoever makes the universe hides messages in transcendental numbers so they'll be read fifteen billion years later when intelligent life finally evolves. I criticized you and Rankin the time we first met for not understanding this. 'If God wanted us to know that he existed, why didn't he send us an unambiguous message?' I asked...
...Palmer, this is the only way. This is the only thing that would convince a skeptic. Imagine we find something. It doesn't have to be tremendously complicated. Just something more orderly than could accumulate by chance that many digits into pi. That's all we need. Then mathematicians all over the world can find exactly the same pattern or message or whatever it proves to be. Then there are no sectarian divisions. Everybody begins reading the same Scripture. No one could then argue that the key miracle in the religion was some conjurer's trick, or that later historians had falsified the record, or that it's just hysteria or delusion or a substitute parent for when we grow up. Everyone could be a believer.