I am not disposed to bewail the limitations imposed by human ignorance. On the contrary, I feel ignorance is a healthful stimulant; and my enforced c… - William Crookes

I have raised a question which may be regarded as heretical. At the time when our modern conception of chemistry first dawned... the average chemist... accepted the elements as ultimate facts... absolutely simple, incapable of transmutation or decomposition, each a kind of barrier behind which we could not penetrate. ...[H]e said they were self-existent from all eternity ...But in our times... we cannot help asking what are the elements, whence do they come, what is their signification? ...These elements perplex us in our researches, baffle us in our speculations, and haunt us in our very dreams. They stretch like an unknown sea before us—mocking, mystifying and murmuring strange revelations and possibilities.
If I venture to say that... elements are not simple and primordial... but have evolved from simpler matters—or... one sole kind of matter—I... give formal utterance to an idea... for some time "in the air" of science. Chemists, physicists, philosophers of the highest merit declare explicitly their belief that the seventy... elements of our text-books are not the which we must never hope to pass.

It is remarkable how much of the utilised information men possess has been derived from the observations of astronomers. The mechanism of the universe was known before Harvey discovered the circulation of the blood, or Watt constructed a steam engine. The astronomers seem to have been the pioneers of every branch of human knowledge. The Old and the New Testament open astronomically: "In the beginning God created the heaven and the earth" (Gen., i., I). "The wise men from the east came to Jerusalem, saying, where is He that is born King of Jews? for we have seen His star in the east" (Matt., ii., 2). It must be remembered that the science of astronomy in one important respect differs from all other sciences. Astronomers are observers only - they ascertain causes by watching effects. They cannot interfere with or alter the causes in operation.

If a possible — nay, reasonable — variation in only one of the forces conditioning the human race, that of gravitation, could so modify our outward form, appearance, and proportions as to make us to all intents and purposes a different race of beings; if mere differences of size can cause some of the most simple facts in chemistry and physics to take so widely different a guise; if beings microscopically small and prodigiously large would simply as such be subject to the hallucinations I have pointed out, and to others I might enlarge upon, is it not possible that we, in turn, though occupying, as it seems to us, the golden mean, may also by the mere virtue of our size and weight fall into misinterpretations of phenomena from which we should escape were we or the globe we inhabit either larger or smaller, heavier or lighter? May not our boasted knowledge be simply conditioned by accidental environments, and thus be liable to a large element of subjectivity hitherto unsuspected and scarcely possible to eliminate?