I think a hero is an ordinary individual who finds the strength to persevere and endure in spite of overwhelming obstacles. The fifteen-year-old boy … - Christopher Reeve

A Hero is an ordinary individual who finds the strength to persevere and endure in spite of overwhelming obstacles.

"Neglect - even misstatement - of recent scientific data was also evident in last year's testimony before this subcommittee by the Christopher Reeve Paralysis Foundation. Mr. Reeve, on behalf of the Foundation, testified that adult stem cells are no substitute for embryonic cells because they cannot be "pluripotent" but are confined to a narrow range of specialization. Yet a few weeks after that hearing, researchers funded by the NIH and the Christopher Reeve Paralysis Foundation published a study indicating that adult bone marrow stem cells "may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases." The first sentence of the published study states: "Pluripotent stem cells have been detected in multiple tissues in the adult, participating in normal replacement and repair, while undergoing self-renewal. The authors cite eleven other studies in support of this observation. Their article, prepared under the aegis of Mr. Reeve's foundation, was received for publication in March 2000, before Mr. Reeve testified in April that adult stem cells cannot be pluripotent.

Now fortunately, even a couple of years before my injury, we were in the dark ages about spinal cord and the common wisdom was that the cord could not regenerate. But I want to say that one of the great heros and really the father of regeneration is a distinguished Canadian who will go down in history as the father of spinal cord recovery. And that is Professor Alberto Aguierro at McGill University. He is the one who discovered that there are two protein molecules at the base of the brain stem. The positive function of these molecules is to stop the brain from overdeveloping during gestation. But then in the adult these protein molecules perform a negative function, they stop the regeneration of nerves in the spinal cord. Now you can chop off your hand then a surgeon can sew it back on again and you can go out and throw a baseball, because of the plasticity and ease with which the peripheral nervous system is able to make appropriate connections. And the good news now for us is that they have discovered nerves regenerate in the spinal cord they seek to find appropriate connections across the injury, across the lesion. And when these appropriate connections are made there will be improvement in sensation and in motor function and depending on the severity of the injury, there are endless possibilities to how much recovery can occur. If someone has been very damaged there may be limitations, if someone is less damaged there may be a better outcome. But the point is, through regeneration the use of human embryonic cells, the use of gene therapy, the spinal cord can and will regenerate and so it is only a question of time before these techniques make their way into humans. One of the most exciting discoveries was made by a Dr. Viscovi in Milan who found that there are cells called epitomal cells which were thought to only exist in again, in the child during gestation, because these cells are undifferentiated and they can become anything. Well, very recently, just two months ago these cells were found to exist in the adult in the ventricles of the brain, in the spinal cord and even in the skin. And this is tremendously exciting because the hope, the best hope for recovery now, is to biopsy these cells from your skin, from your hand for example, they could grow hundreds of thousands of cells in a petri dish and genetically instruct them to become neurons and axons. They would then be injected inside of the injury and they would become the nerves necessary to carry messages from the brain to the rest of the body. Now that would have been science fiction a few years ago, but it's here and it's happening and it doesn't matter whether it's an acute injury or a chronic injury. So I offer you the specific detail, not to give you a boring science lecture but to tell you there is very real tangible hope, very real hope...And one of the great advantages of this technique is that there is no danger of toxicity to the body or rejection by the immune system. And what I love about it is the body is healing itself. Taking cells from one part and using them in another area and I think that's some-how a beautiful design, rather than loading up the body with more chemicals and more drugs and more artificial agents.

I work with Dr. John McDonald at Washington University in St. Louis, and he is a very knowledgeable researcher on (Inaudible) stem cells, and a few years ago he said to me that in order to cure my particular condition, which is demyelination of nerves in a very small area of the spinal cord, right at the second cervical vertebrae, that if you imagine the rubber coating around a wire that allows conductivity of electricity, the same thing as with nerves, myelin is like that rubber coating. It's a fatty substance that if it comes off of the nerves, then signals do not go from the brain down to the spinal cord as required. However, it is possible, and he's demonstrated this as graphic(?) as possible, to re-myelinate. Now, a few years ago, he said, we would be willing to inject human embryonic stem cells into you and hope for the best. But hoping for the best is a very dangerous proposition for people with spinal cord injuries because our spinal cord injury affects every organ in the body, and the most serious side effect is that it severely compromises the immune system, so spinal cords patients, particularly with high level injuries like mine, are prone first to pneumonia, which I've had at least five times since my injury, many patients often die from that. Also, it compromises the cardiovascular system, compromises the digestive tract, the ... your whole bowel-bladder-sexual function, skin integrity and also bone density, so that osteoporosis becomes a very ... a very critical factor. So literally he said to me that the immunosuppression that would be required just to inject 30million human embryonic stem cells from an anonymous donor might kill me. And now, he would be unwilling as a doctor, because of the ethics involved that a doctor is ethically bound to give his patients the best possible treatment, he would not inject me with embryonic stemcells unless we go the other route, which is therapeutic cloning- taking an egg, removing the nucleus, taking DNA from my skin and deriving stem cells from that, which would be injected in a manner that would probably not be rejected by my immune system. So my future, and others would agree, many scientists would agree, my future, in terms of being able to recover will depend on some way of delivering stem cells without compromising my immune system and therapeutic cloning, which would use my DNA is the best hope.