metformin - David A. Sinclair

In my mind, there are few sins so egregious as extending life without health. This is important. It does not matter if we can extend lifespans if we cannot extend healthspans to an equal extent. And so if we're going to do the former, we have an absolute moral obligation to do the latter.

But consider this: though smoking increases the risk of getting cancer fivefold, being 50 years old increases your cancer risk a hundredfold. By the age of 70, it is a thousandfold

As the venture capitalist and "very large yacht" owner Nick Hanauer wrote in a memo to "My Fellow Zillionaires" in 2014, there is no example in human history where wealth accumulated like this and the pitchforks didn't eventually come out. You show me a highly unequal society, and I will show you a police state. Or an uprising. There are no counterexamples. None. . . . We will not be able to predict when, and it will be terrible — for everybody. But especially for us.