This group of boys showed considerable: and consistent effects from medication with UML or LSD daily for two to eleven months. Their behavior, ward m… - Lauretta Bender

We do not use it as a psychoanalytic tool. Our idea was to give it as a daily drug. It is our general experience that frequently the children respond to many drugs that affect the central nervous system differently than adults. This is common knowledge; at least, to those of us using drugs with children. So we were not surprised to find, in our early initial studies, that if the children were near puberty or in puberty they responded to the first dose with anxiety and disturbance, just as the adolescent boys did. But even these children could be maintained on high doses of the drug, just as the adolescent boys were, so that the drugs can be given to these children in continuing doses. What tolerance means, I don't know. Tolerance may be established in our patients. The chemical studies suggest this, and even our psychological studies indicate a slight change later on, a leveling off of response as compared to initial reaction, but the long-term reaction is still the most valuable reaction to the drug.

It was hoped that these drugs might prove effective in breaking through autistic defenses, improving autonomic nervous system functioning, and modifying distorted perceptual experiences. There were some differences in results in the various groups. In general, the younger autistic children became less anxious, less autistic and plastic, more aware and responsive, with some changes in verbalization and qualitative improvement, on the Vineland Social Maturity Scale. The girls and older autistic boys showed similar results, but much less marked and persistent. Verbal children showed improvement in general behavior, with marked changes in fantasy and bizarre ideation to more insightful, reality-oriented, though often anxious and depressive attitudes, and improved maturity and organization. There were no major side effects, though a few patients on UML had muscular spasms and vasomotor changes in the legs, generally of a temporary nature. It is significant to note that while most of these patients had required tranquilizing or, other medications, they could all now be maintained only on the LSD or UML. A few patients received reserpine to control excessive activity, aggression, or biting.

Mr. BEASER: Now, let me ask you one final question, Doctor. Would you say ─ I suppose you would ─ that your opinion on this subject is in no way in influenced by the fact that you are member of the Superman comics advisory board?