I shivered in the knowledge of the futility of all ambition. My mouth was sour with the yellow recollection of death and blood-smeared fields and wal… - William Styron

Writers ever since writing began have had problems, and the main problem narrows down to just one word — life. Certainly this might be an age of so-called faithlessness and despair we live in, but the new writers haven’t cornered any market on faithlessness and despair, any more than Dostoyevsky or Marlowe or Sophocles did. Every age has its terrible aches and pains, its peculiar new horrors, and every writer since the beginning of time, just like other people, has been afflicted by what that same friend of mine calls “the fleas of life”—you know, colds, hangovers, bills, sprained ankles, and little nuisances of one sort or another. They are the constants of life, at the core of life, along with nice little delights that come along every now and then.

"On Major Depression, quoted by the great William Styron of Sophie's Choice & Darkness Visible:
From Darkness Visible, William Styron

"It is a positive and active anguish, a sort of psychical neuralgia, wholly unknown to normal life.

When At Play in the Fields of the Lord was published in 1965 there was revealed in stunning outline the fully realized work of a novelist writing at white heat and at the peak of his powers; [...] Peter is a poet and a scientist, and the mingling of these two personae has given us such carefully observed, unsentimental, yet lyrically echoing works as The Cloud Forest, Under the Mountain Wall, The Tree where Man was Born and The Snow Leopard. [...] We behold a writer of phenomenal scope and versatility.