The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life. This project is ambitious … - David Pearce

[U]nlike positive utilitarianism or so-called preference utilitarianism - neither of which can ever be wholly fulfilled - [negative utilitarianism] seems achievable in full.

I think there's an asymmetry. There's this fable of Ursula Le Guin, short story, Ones Who Walk Away From Omelas. We're invited to imagine this city of delights, vast city of incredible wonderful pleasures but the existence of Omelas, this city of delights depends on the torment and abuse of a single child. The question is would you walk away from Omelas and what does walking away from Omelas entail. Now, personally I am someone who would walk away from Omelas. The world does not have an off switch, an off button and I think if one is whether a Buddhist of a negative utilitarian, or someone who believes in suffering-focused ethics, rather than to consider these theoretical apocalyptic scenarios it is more fruitful to work with secular and religious life lovers to phase out the biology of suffering in favor of gradients of intelligent wellbeing because one of the advantages of hedonic recalibration, i.e. ratcheting up hedonic set points is that it doesn't ask people to give up their existing values and preferences with complications.

Here the question comes down to an analysis of risk-reward ratios - and our basic ethical values, themselves shaped by our evolutionary past. Lest extension of the new reproductive medicine seem too rashly experimental even to contemplate, it's worth recalling that each act of old-fashioned sexual reproduction is itself an untested genetic experiment, the outcome of random mutations and meiotic shuffling of the genetic deck, and with no happy ending to date. So just who are we to accuse of reckless gambling? As it stands, all of us are genetically predestined to grow old and die; and in the course of a lifetime, the great majority of humans will experience periods of intense psychological distress, for instance loneliness and heartache after an unhappy love affair. Our social primate biology ensures that most of us sometimes experience, to a greater or lesser degree, all manner of nasty states that were genetically adaptive in the ancestral environment e.g. jealousy, resentment, anger, and so forth. Hundreds of millions of people in the world today suffer bouts of depression; others live with chronic anxiety. One might say these phenotypes are part of what it means to be human. Worse, we pass a heritable predisposition to these horrible states on to our children.