Perrin... showed in 1895 that the rays deposit negative electrical charge on a charge collector... inside... the tube. - Steven Weinberg

It is with Isaac Newton that the modern dream of a final theory really begins.

It is almost irresistible for humans to believe that we have some special relation to the universe, that human life is not just a more-or-less farcical outcome of a chain of accidents reaching back to the first three minutes, but that we were somehow built in from the beginning. ... It is very hard to realise that this is all just a tiny part of an overwhelmingly hostile universe. It is even harder to realise that this present universe has evolved from an unspeakably unfamiliar early condition, and faces a future extinction of endless cold or intolerable heat. The more the universe seems comprehensible, the more it also seems pointless.

In the Standard Model the masses of quarks and leptons take values proportional to the coupling constants in the interaction of these fermions with scalar fields, constants that in the context of this model are entirely arbitrary. But the peculiar hierarchical pattern of lepton and quark masses seems to call for a larger theory, in which in some leading approximation the only quarks and leptons with non-zero mass are those of the third generation, the tau, top, and bottom, with the other lepton and quark masses arising from some sort of radiative correction. Such theories were actively considered ... soon after the completion of the Standard Model, but interest in this program seems to have lapsed subsequently ...