The need for a fundamentally different approach to the study of physical processes at the molecular level motivated the development of relevant stati… - George Klir

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The need for a fundamentally different approach to the study of physical processes at the molecular level motivated the development of relevant statistical methods, which turned out to be applicable not only to the study of molecular processes (statistical mechanics), but to a host of other areas such as the actuarial profession, design of large telephone exchanges, and the like. In statistical methods, specific manifestations of microscopic entities (molecules, individual telephone sites, etc.) are replaced with their statistical averages, which are connected with appropriate macroscopic variables. The role played in Newtonian mechanics by the calculus, which involves no uncertainty, is replaced in statistical mechanics by probability theory, a theory whose very purpose is to capture uncertainty of a certain type.