If we already lived in a cruelty-free world, the notion of re-introducing suffering, exploitation and creatures eating each other would seem not so m… - David Pearce

[A]s well as seriously – indeed exhaustively – researching everything that could conceivably go wrong, I think we should also investigate what could go right. The world is racked by suffering. The hedonic treadmill might more aptly be called a dolorous treadmill. Hundreds of millions of people are currently depressed, pain-ridden or both. Hundreds of billions of non-human animals are suffering too. If we weren't so inured to a world of pain and misery, then the biosphere would be reckoned in the throes of a global medical emergency. Thanks to breakthroughs in biotechnology, pain-thresholds, default anxiety levels, hedonic range and hedonic set-points are all now adjustable parameters in human and non-human animals alike. We are living in the final century of life on Earth in which suffering is biologically inevitable. As a society, we need an ethical debate about how much pain and misery we want to preserve and create.

[H]ere we come to the nub of the issue: the alleged moral force of the term "natural". If any creature, by its very nature, causes terrible suffering, albeit unwittingly, is it morally wrong to change that nature? If a civilised human were to come to believe s/he had been committing acts that caused grievous pain for no good reason, then s/he would stop - and want other moral agents to prevent the recurrence of such behaviour. May we assume that the same would be true of a lion, if the lion were morally and cognitively "uplifted" so as to understand the ramifications of what (s)he was doing? Or a house cat tormenting a mouse? Or indeed a human sociopath?

The biology of suffering in intelligent agents is a deep underlying source of existential risk – and one that can potentially be overcome.