There is nothing your knife handlers can do in the way of rioting and demonstrating that will have any permanent effect as long as, in the extremity,… - Isaac Asimov

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There is nothing your knife handlers can do in the way of rioting and demonstrating that will have any permanent effect as long as, in the extremity, there is an army equipped with kinetic, chemical, and neurological weapons that is willing to use them against your people. You can get all the downtrodden and even all the respectables on your side, but you must somehow win over the security forces and the Imperial army or at least seriously weaken their loyalty to the rulers.