Competence can step in where popularity cannot go. - Jordan Peterson

The Bible presents a cataclysm at the beginning of time, which is the emergence of self-consciousness in human beings, which puts a rift in the structure of Being. That's the right way to think about it. That's given cosmic significance. You can dispense with that and say that nothing that happens to human beings is of cosmic significance, that we're these short lived, mold-like entities that are like cancers on this tiny little planet, rotating out in the middle of nowhere on the edge of some unknown galaxy in the middle of infinite space, and nothing that happens to us matters.
This is not a road that you can walk down and live well. For all intents and purposes, it's untrue. If fact, if you really walk down that road, and you take it really seriously, you end up not living at all. The kind of conclusions suicidal people draw about the utility of life, prior to wishing for its cessation, are very much like the conclusions that you draw if you walk down that particular line of reasoning long enough.

You must determine where you have been in your life, so that you can know where you are now. If you don’t know where you are, precisely, then you could be anywhere. Anywhere is too many places to be, and some of those places are very bad. You must determine where you have been in your life, because otherwise you can’t get to where you’re going. You can’t get from point A to point B unless you are already at point A, and if you’re just “anywhere” the chances you are at point A are very small indeed. You must determine where you are going in your life, because you cannot get there unless you move in that direction. Random wandering will not move you forward. It will instead disappoint and frustrate you and make you anxious and unhappy and hard to get along with (and then resentful, and then vengeful, and then worse). Say what you mean, so that you can find out what you mean. Act out what you say, so you can find out what happens. Then pay attention. Note your errors. Articulate them. Strive to correct them. That is how you discover the meaning of your life. That will protect you from the tragedy of your life. How could it be otherwise? Confront the chaos of Being. Take aim against a sea of troubles. Specify your destination, and chart your course. Admit to what you want. Tell those around you who you are. Narrow, and gaze attentively, and move forward, forthrightly. Be precise in your speech.

Mark Twain once said, “It’s not what we don’t know that gets us in trouble. It’s what we know for sure that just ain’t so.