In depression this faith in deliverance, in ultimate restoration, is absent. The pain is unrelenting, and what makes the condition intolerable is the… - William Styron

There is a region in the experience of pain where the certainty of alleviation often permits superhuman endurance. We learn to live with pain in varying degrees daily, or over longer periods of time, and we are more often than not mercifully free of it. When we endure severe discomfort of a physical nature our conditioning has taught us since childhood to make accommodations to the pain’s demands — o accept it, whether pluckily or whimpering and complaining, according to our personal degree of stoicism, but in any case to accept it. Except in intractable terminal pain, there is almost always some form of relief; we look forward to that alleviation, whether it be through sleep or Tylenol or self-hypnosis or a change of posture or, most often, through the body’s capacity for healing itself, and we embrace this eventual respite as the natural reward we receive for having been, temporarily, such good sports and doughty sufferers, such optimistic cheerleaders for life at heart. In depression this faith in deliverance, in ultimate restoration, is absent. The pain is unrelenting, and what makes the condition intolerable is the foreknowledge that no remedy will come — not in a day, an hour, a month, or a minute. If there is mild relief, one knows that it is only temporary; more pain will follow. It is hopelessness even more than pain that crushes the soul. So the decision-making of daily life involves not, as in normal affairs, shifting from one annoying situation to another less annoying — or from discomfort to relative comfort, or from boredom to activity — but moving from pain to pain. One does not abandon, even briefly, one's bed of nails, but is attached to it wherever one goes.

I felt loss at every hand. The
loss of self-esteem is a celebrated symptom, and my own sense of self
had all but disappeared, along with any self-reliance. This loss can
quickly degenerate into dependence, and from dependence into infantile
dread. One dreads the loss of all things, all people close and dear.
There is an acute fear of abandonment.

Simon Wiesenthal, the head of the Jewish Center of Documentation in Vienna, expressed his feelings on the matter in a recent interview: "[...] I've battled for years with Jewish organisations, warning them that we shouldn't always talk about the six million Jews who died in the Holocaust. I say let's talk about eleven million civilians, among them six million Jews, who were killed. It's our Jewish fault that in the eyes of the world this whole problem became reduced to the problem between the Nazis and the Jews; the problem obviously was much broader."