Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that,… - Eric Kandel

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Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that, in the brain as in bacteria, genes are also servants of the environment. ...An environmental stimulus... activates modulatory interneurons that release serotonin. The serotonin acts on the sensory neuron to increase cyclic AMP and to cause protein kinase A and MAP kinase to move to the nucleus and activate CREB. The activation of CREB, in turn, leads to the expression of genes that changes the function and the structure of the cell.

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About Eric Kandel

Eric Richard Kandel (born November 7, 1929) is an Austrian-American neuropsychiatrist and recipient of the 2000 Nobel Prize in Physiology or Medicine, shared with Arvid Carlsson and Paul Greengard. His research entails the physiological basis of memory storage in neurons.

Also Known As

Native Name: Eric Richard Kandel
Alternative Names: Erich Richard Kandel Erich Kandel Eric R. Kandel Eric R Kandel E. R. Kandel E R Kandel E. Kandel E Kandel Kandel Kandel E Kandel E. Kandel E. R. Kandel ER
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Cori Bargmann... has studied two variants of C. elegans... The only difference between the two is one amino acid in an otherwise shared receptor protein. Transferring the receptor from a social worm to a solitary worm makes the solitary worm social.

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Jacques Monod... published a paper entitled "Genetic Regulatory Mechanisms in the Synthesis of Protein." Using bacteria as a model system, they made the remarkable discovery that genes can be regulated—that is, they can be switched on and off like a water faucet.

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