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" "Even though I had long been taught that the genes of the brain are the governors of behavior, the absolute masters of our fate, our work showed that, in the brain as in bacteria, genes are also servants of the environment. ...An environmental stimulus... activates modulatory interneurons that release serotonin. The serotonin acts on the sensory neuron to increase cyclic AMP and to cause protein kinase A and MAP kinase to move to the nucleus and activate CREB. The activation of CREB, in turn, leads to the expression of genes that changes the function and the structure of the cell.
Eric Richard Kandel (born November 7, 1929) is an Austrian-American neuropsychiatrist and recipient of the 2000 Nobel Prize in Physiology or Medicine, shared with Arvid Carlsson and Paul Greengard. His research entails the physiological basis of memory storage in neurons.
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