Medicines are very unusual among technologies in that faith in them preceded efficacy. - Paul Graham

If you want to make money at some point, remember this, because this is one of the reasons startups win. Big companies want to decrease the standard deviation of design outcomes because they want to avoid disasters. But when you damp oscillations, you lose the high points as well as the low. This is not a problem for big companies, because they don't win by making great products. Big companies win by sucking less than other big companies.

You might find contradictory taboos. In one culture it might seem shocking to think x, while in another it was shocking not to. But I think usually the shock is on one side. In one culture x is ok, and in another it’s considered shocking. My hypothesis is that the side that’s shocked is most likely to be the mistaken one.

it was not till the Industrial Revolution that wealth creation definitively replaced corruption as the best way to get rich.