The researcher hoping to break new ground in the theory of experimental design should involve himself in the design of actual experiments. The invest… - George E. P. Box

For the theory-practice iteration to work, the scientist must be, as it were, mentally ambidextrous; fascinated equally on the one hand by possible meanings, theories, and tentative models to be induced from data and the practical reality of the real world, and on the other with the factual implications deducible from tentative theories, models and hypotheses.

An innovative discussion of building empirical models and the fitting of surfaces to data. Introduces the general philosophy of response surface methodology, and details least squares for response surface work, factorial designs at two levels, fitting second-order models, adequacy of estimation and the use of transformation, occurrence and elucidation of ridge systems, and more. Some results are presented for the first time. Includes real-life exercises, nearly all with solutions.

A mechanistic model has the following advantages: 1. It contributes to our scientific understanding of the phenomenon under study. 2. It usually provides a better basis for extrapolation (at least to conditions worthy of further experimental investigation if not through the entire range of all input variables). 3. It tends to be parsimonious (i.e, frugal) in the use of parameters and to provide better estimates of the response