This history of civilization proves beyond doubt just how sterile the repeated attempts of metaphysics to guess at nature' s laws have been. Instead,… - Santiago Ramón y Cajal

The intellect is presented with phenomena marching in review before the sensory organs. It can be truly useful and productive only when limiting itself to the modest tasks of observation, description, and comparison, and of classification that is based on analogies and differences. A knowledge of underlying causes and empirical laws will then come slowly through the use of inductive methods.

There is no doubt that the human mind is fundamentally incapable of solving these formidable problems (the origin of life, nature of matter, origin of movement, and appearance of consciousness). Our brain is an organ of action that is directed toward practical tasks; it does not appear to have been built for discovering the ultimate causes of things, but rather for determining their immediate causes and invariant relationships.

As Claude Bernard has pointed out, researchers cannot transcend the determinism of phenomena; instead, their mission is limited to demonstrating the how, never the why, of observed changes. This is a modest goal in the eyes of philosophy, yet an imposing challenge in actual practice.