We are in the end game, I'm optimistic that we will be successful. I'm personally very committed. - Bill Gates

I'd like to start by telling you about my wife Melinda's Aunt Myra. We see her a few times a year. Aunt Myra worked for many years taking reservations for Delta Airlines. She lived in New Orleans until Hurricane Katrina, and then she moved to Dallas, Melinda's hometown. She loves to see our kids. When we all get together, she'll sit down on the floor and play games with them. Aunt Myra also has polio. She's in braces, and she has been ever since she was a little girl. Our children only know what polio is because of their aunt. Otherwise, the disease would just be another historical fact they learn about in school. In fact, even though I was born just three years after one of the worst polio epidemics in American history, I didn't know anyone with polio when I was growing up. That's how far we've come.

Unfortunately, many programs are so big that there is no one individual who really knows all the pieces, and so the amount of code sharing you get isn't as great. Also, the opportunity to go back and really rewrite something isn't quite as great, because there's always a new set of features that you're adding on to the same program.

First we've got population. Now, the world today has 6.8 billion people. That's headed up to about nine billion. Now, if we do a really great job on new vaccines, health care, reproductive health services, we could lower that (forecast) by, perhaps, 10 or 15 percent, but there we see an increase of about 1.3 (per year).