It helps to set ambitious goals and commit to meeting them, the way countries around the world did with the 2015 Paris Agreement. It’s easy to mock international agreements, but they’re part of how progress happens: If you like having an ozone layer, you can thank an international agreement called the Montreal Protocol.

Before Paul and I started the company, we had been involved in some large-scale software projects that were real disasters. They just kept pouring people in, and nobody knew how they were going to stabilize the project. We swore to ourselves that we would do better.

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One of the wonderful things about the information highway is that virtual equity is far easier to achieve than real-world equity...We are all created equal in the virtual world and we can use this equality to help address some of the sociological problems that society has yet to solve in the physical world,"

When I was a kid, the disaster we worried about most was a nuclear war. That's why we had a barrel like this down in our basement, filled with cans of food and water. When the nuclear attack came, we were supposed to go downstairs, hunker down, and eat out of that barrel. Today, the greatest risk of global catastrophe doesn't look like this. Instead, it looks like this. If anything kills over 10 million people in the next few decades, it's most likely to be a highly infectious virus rather than a war. Not missiles, but microbes.

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First we've got population. Now, the world today has 6.8 billion people. That's headed up to about nine billion. Now, if we do a really great job on new vaccines, health care, reproductive health services, we could lower that (forecast) by, perhaps, 10 or 15 percent, but there we see an increase of about 1.3 (per year).

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We would like every country to be self-sufficient so that both in terms of running a good primary health care system and funding a good primary health care system, it's all OK, and they just participate in regional bodies that have standby capacity to deal with these things. Africa, of all the places in the world, is the furthest behind on being able to do that. And through aid, health and health systems in Africa have improved very, very dramatically.

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