I think it's somewhat of a happy coincidence so far that most breakthroughs have been good. To say, I see a breakthrough on the horizon. Is that good… - Holden Karnofsky

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I think it's somewhat of a happy coincidence so far that most breakthroughs have been good. To say, I see a breakthrough on the horizon. Is that good or bad? How can we prepare for it? That's another thing academia is really not set up to do. Academia is set up to get the breakthrough. That is a question I ask myself a lot is here's an intellectual activity. Why can't it be done in academia? These days, my answer is if it's really primarily of interest to a very cosmopolitan philanthropist trying to help the whole future, and there's no one client and it's not frontier advancing, then I think that does make it pretty plausible to me that there's no one doing it. We would love to change that, at least somewhat, by funding what we think is the most important work.

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About Holden Karnofsky

Holden Karnofsky is an American nonprofit executive. He is a co-founder and co-chief executive officer of the research and grantmaking organization Open Philanthropy. Karnofsky co-founded the charity evaluator GiveWell with Elie Hassenfeld in 2007 and is vice chair of its board of directors.

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I have more pet peeves than anyone else I know, and one of the very biggest ones is what I call flakes: people who say they'll do something, then back out without giving me the communication I need to adjust my plans. Anyone who's ever stood me up, or even been very late to something without a heads-up phone call, or just forgotten to do something they knew I was counting on them to do, has felt my wrath … thanks to cellphones and email, there is just no excuse.

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