The harsh mathematics of polio makes it clear: We cannot maintain a level of one thousand or two thousand cases a year. Either we eradicate polio, or we return to the days of tens of thousands of cases per year. That is no alternative at all. We don't let children die because it is fatiguing to save them. Our commitment as a foundation is to work with partners until no children die from polio.

This leads to the paradox, that because the disease is only in the poor countries, there is not much investment. For example, there is more money put into baldness drugs, than are put into malaria. Now, baldness, it is a terrible thing [audience laughter] and rich men are afflicted, so that is why that priority is set.

One of the wonderful things about the information highway is that virtual equity is far easier to achieve than real-world equity...We are all created equal in the virtual world and we can use this equality to help address some of the sociological problems that society has yet to solve in the physical world,"

Before Paul and I started the company, we had been involved in some large-scale software projects that were real disasters. They just kept pouring people in, and nobody knew how they were going to stabilize the project. We swore to ourselves that we would do better.

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Unfortunately, many programs are so big that there is no one individual who really knows all the pieces, and so the amount of code sharing you get isn't as great. Also, the opportunity to go back and really rewrite something isn't quite as great, because there's always a new set of features that you're adding on to the same program.

You've got to be willing to read other people's code, and then write your own, then have other people review your code. You've got to want to be in this incredible feedback loop where you get the world-class people to tell you what you're doing wrong...

The best way to prepare [to be a programmer] is to write programs, and to study great programs that other people have written. In my case, I went to the garbage cans at the Computer Science Center and fished out listings of their operating system.

One of the best things I read was an 1889 essay by Andrew Carnegie called The Gospel of Wealth. It makes the case that the wealthy have a responsibility to return their resources to society, a radical idea at the time that laid the groundwork for philanthropy as we know it today.

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