David A. Sinclair Quotes

There isn't much debate on the downsides of consumption of animal protein. Study after study has demonstrated that heavily animal-based diets are associated with high cardiovascular mortality and cancer risk.

Why would we choose to focus on problems that impact small groups of people if we could address the problem that impacts everyone — especially if, in doing so, we could significantly impact all those other, smaller problems?

In the same way that genetic information is stored as DNA, epigenetic information is stored in a structure called chromatin.

the evidence is irrefutable: if you believe climate change is a threat, you can't say that GMOs are, because the evidence that GMOs are safe is stronger than the evidence that climate change is occurring.

What's the upward limit? I don't think there is one. Many of my colleagues agree.14 There is no biological law that says we must age.15 Those who say there is don't know what they're talking about. We're probably still a long way off from a world in which death is a rarity, but we're not far from pushing it ever farther into the future.

Die köstlichsten Erdbeeren wurden durch Phasen mit begrenzter Wasserzufuhr gestresst.

The tragedy of the commons is that humans are not very good at taking personal action to solve collective problems. The trick to revolutionary change is finding ways to make self-interest align with the common good. For people to accept widespread biometric tracking in a way that could help us get ahead of fast-moving deadly viruses, they'll need to be offered something they have a hard time seeing themselves without.

In 2003, Michael McBurney from the University of Ottawa in Canada discovered that mouse embryos manipulated to be unable to produce one of the seven sirtuin enzymes, SIRT1, couldn't last past the fourteenth day of development — about two-thirds of the way into a mouse's gestation period.26 Among the reasons, the team reported in the journal Cancer Cell, was an impaired ability to respond to and repair DNA damage.

Do your part to make humanity be the best it can be. Don't waste a moment. Embrace your youth; hold on to it for as long as you can. Fight for it. Fight for it. Never stop fighting for it.

What I'm suggesting is that the SIR2 gene in yeast and the SIRT genes in mammals are all descendants of gene B, the original gene silencer in M. superstes.30 Its original job was to silence a gene that controlled reproduction.

The other pathway is a metabolic control enzyme known as AMPK, which evolved to respond to low energy levels. It has also been highly conserved among species and, as with sirtuins and TOR, we have learned a lot about how to control it.

But now I am six, I'm as clever as clever. So I think I'll be six now for ever and ever.

And in his 1995 book, The Road Ahead, Bill Gates made no mention of the internet, though he substantially revised it about a year later, humbly admitting that he had “vastly underestimated how important and how quickly” the internet would come to prominence.2

The way doctors treat illness today "is simple," wrote S. Jay Olshansky, a demographer at the University of Illinois. "As soon as a disease appears, attack that disease as if nothing else is present; beat the disease down, and once you succeed, push the patient out the door until he or she faces the next challenge; then beat that one down. Repeat until failure."

If you've had your genome analyzed, you can check if you have any of the known variations of FOXO3 that are associated with a long life.40 For example, having a C instead of a T variant at position rs2764264 is associated with longer life. Two of our children, Alex and Natalie, inherited two Cs at this position, one from Sandra and one from me, so all other genes being equal, and as long as they don't live terribly negative lifestyles, they should have greater odds of reaching age 95 than I do, with my one C and one T, and substantially greater than someone with two Ts.