[W]e can't agree among ourselves, as an origins of life community, what were the conditions... under which life arose on earth. ...Within the field itself, probably the leading candidate... would be terrestrial geothermal systems, starting with and powered by UV radiation. There's been a lot of rather beautiful chemistry... in a terrestrial environment in some kind of geothermal pool... and cyanide chemistry, it works well as chemistry. The problem I have with that is that it doesn't link up very well to biochemistry of cells. I'm a biochemist and I would like to see some continuity between and , and there's not much there, to me. That doesn't mean that it's wrong. It's just that... [I] would like to see some continuity.

I'm... interested in the principles of what governs the emergence of life on the planet, with a certain set of resources. Can we understand it? We'll never know what happened, so we'll never know how life started on earth. ...[I]f those principles are enormously difficult, if it turns out that it's a freak statistical accident, then there's little point in studying it and we will gain... very little. If, on the other hand, those principles are reasonable, intelligible, that we can study them in the lab and demonstrate that the steps that we propose are plausible and... we can demonstrate it, then I think that's as close to understanding the origin of life [as] we can get. ...[I]f those principles are generalizable, then as a scientist, that's... a pleasing thing. I'm not sure there's any more that's more pleasing to me, personally as a scientist.

We also have a power to destroy the earth, and... it's probably unique. ...Destroy ourselves, destroy a large part of life in earth, not the bacteria... If we take ourselves out, we'll give it five million years and it will be indistinguishable, apart from ourselves.

I think we share consciousness right across... not just even the animal world. I would see it going down even to the level of cells, some kind of flickering of consciousness. So I don't feel alone on earth, but I do think that there is something different about humans.

They [bacteria] haven't used it [their more complex metabolism]... to give rise to more complex morphologies beyond the kind of stromatolite type structures, beyond s. That seems to be a limit. Some multicellularity, some degree of differentiation and complexity, but nothing... to compare with the flea.

[W]e are biochemically quite simple in comparison bacteria. Simpler than bacteria. In terms of our metabolic biochemistry we are really limited. ...[W]e have ...across the entire domain of s, about the same degree of metabolic sophistication as a single bacterial cell.

I would define complexity, not really as genetic complexity because if you take it purely as genetic complexity, E. coli... a single cell may have 4,000 genes but the metagenome, the pool of genes in E. coli around the place may be on the order to 30,000 or more... [T]hat's the level of complexity equivalent to the human genome, or even more complex than the human genome, but it's organized and structured in a different way. ...You might say that it's structured in a similar way to an ... but I think an ant colony has taken that level of Eusocial behavior a long way beyond anything you would see in E. coli. So I would define it as morphologically complex, meaning cells are larger and have a lot of stuff in them.

What is [life] it? Would we even recognize it. What I imagine we would find would be cell-like things. Not a million miles away from bacteria, using , probably in water, not because it's the only way of organizing. It's just that carbon is very good at that kind of chemistry. It's very common in the universe. Water is ubiquitous. We know, from the principles of life on earth, that all this stuff works and we know that it's thermodynamically favored. ...[J]ust statistically, I would expect, maybe 900 times out of a thousand that life would be organized in a similar way to life here. That's not to say it can't be different. It's just probably... going to be similar.

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It would be a little disappointing if we didn't even find bacteria in our own solar system. I would be rather surprised to find what I would describe as large, morphologically complex life. ...It only arose once on earth. That doesn't necessarily mean that it's improbable... but it does raise some interesting questions about why, and... I think we can apply principles to it, and those principles effectively are why do bacteria and , as assistive groups to the bacteria... They're biochemically very complex. They're genetically very complex. They're kind of structured in a different way where they have large, complex metagenomes, but... I doubt very much that we'll ever find anything of the [morphological] level of complexity of a flea, composed of bacterial cells.