For a while I was most well known for that [the Janis Joplin album cover], and for “Keep on Truckin’.” That was a drawing that came out of LSD trips, and the words came from a Blind Boy Fuller song from 1935. I drew it in my sketchbook and then for Zap. It sort of caught the popular imagination. It became a horrible popular thing.

When I come up against the real world, I just vacillate.

Before industrial civilization, local and regional communities made their own music, their own entertainment. The esthetics were based on traditions that went far back in time—i.e. folklore. But part of the con of mass culture is to make you forget history, disconnect you from tradition and the past. Sometimes that can be a good thing. Sometimes it can even be revolutionary. But tradition can also keep culture on an authentic human level, the homespun as opposed to the mass produced. Industrial civilization figured out how to manufacture popular culture and sell it back to the people. You have to marvel at the ingenuity of it! The problem is that the longer this buying and selling goes on, the more hollow and bankrupt the culture becomes. It loses its fertility, like worn out, ravaged farmland. Eventually, the yokels who bought the hype, the pitch, they want in on the game. When there are no more naive hicks left, you have a culture where everybody is conning each other all the time. There are no more earnest "squares" left—everybody's "hip", everybody is cynical.

My generation comes from a world that has been molded by crass TV programs, movies, comic books, popular music, advertisements and commercials. My brain is a huge garbage dump of all this stuff and it is this, mainly, that my work comes out of, for better or for worse. I hope that whatever synthesis I make of all this crap contains something worthwhile, that it's something other than just more smarmy entertainment—or at least, that it's genuine high quality entertainment. I also hope that perhaps it's revealing of something, maybe. On the other hand, I want to avoid becoming pretentious in the eagerness to give my work deep meanings! I have an enormous ego and must resist the urge to come on like a know-it-all. Some of the imagery in my work is sorta scary because I'm basically a fearful, pessimistic person. I'm always seeing the predatory nature of the universe, which can harm you or kill you very easily and very quickly, no matter how well you watch your step. The way I see it, we are all just so much chopped liver. We have this great gift of human intelligence to help us pick our way through this treacherous tangle, but unfortunately we don't seem to value it very much. Most of us are not brought up in environments that encourage us to appreciate and cultivate our intelligence. To me, human society appears mostly to be a living nightmare of ignorant, depraved behavior. We're all depraved, me included. I can't help it if my work reflects this sordid view of the world. Also, I feel that I have to counteract all the lame, hero-worshipping crap that is dished out by the mass-media in a never-ending deluge.

As a matter of survival I've created this anti-hero alter-ego, a guy in an ill-fitting suit—part humunculus and part clown. Yep, that's me alright … I could never relate to heroes. I have no interest in drawing heroic characters. It's not my thing, man. I'm more inclined toward the sordid underbelly of life. I find it more interesting to draw grotesque, lurid, or absurd pictures, and I especially enjoy depicting my fevered sexual obsessions.

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Killing yourself is a major commitment, it takes a kind of courage. Most people just lead lives of cowardly desperation. It's kinda half suicide where you just dull yourself with substances.

I’m an outsider. I will always be an outsider.

I knew I was weird by the time I was four. I knew I wasn't like other boys. I knew I was more fearful. I didn't like the rough and tumble most boys were into. I knew I was a sissy.

I was taking LSD periodically, every couple of months. I was in a strange state of mind, influenced by these visions. … I was trying to draw it in my sketchbook, and that began to coalesce into these comic strips that were stylistically based on grotesque, vulgar humor comics of the thirties and forties. … All of those characters came out of that crazy visionary period that I couldn’t shut off. It was spontaneous, but I was so crazy, I was really out of my mind, it was like schizophrenia. It was like what produces art by crazy people in a madhouse. Anything could be an influence, anything I heard. I was in Chicago in early ’66 and the radio was on, there was some tune playing, it was a black station, and this announcer said, That was Mr. Natural. I just started drawing Mr. Natural, this bearded guru-type character in my sketchbook, it just came out.