Over the last few decades, physics in the grand mode practiced by Hawking and Rees has become increasingly disconnected from empirical evidence. Prop… - John Horgan

In Theories of Everything... John Barrow argued that Gödel's incompleteness theorem undermines the very notion of a complete theory of nature. Gödel established that any moderately complex system of axioms inevitably raises questions that cannot be answered about the axioms. The implication is that any theory will always have loose ends. Barrow also pointed out that a unified theory of particle physics would not really be a theory of everything, but only a theory of all particles and forces. The theory would have little or nothing to say about phenomena that make our lives meaningful, such as love or beauty.

Physicists do not believe quantum mechanics because it explains the world, but because it predicts the outcome of experiments with almost miraculous accuracy. Theorists kept predicting new particles and other phenomena, and experiments kept bearing out those predictions.

Our descendants will learn much more about nature, and they will invent gadgets even cooler than smart phones. But their scientific version of reality will resemble ours, for two reasons: First, ours… is in many respects true; most new knowledge will merely extend and fill in our current maps of reality rather than forcing radical revisions. Second, some major remaining mysteries—Where did the universe come from? How did life begin? How, exactly, does a chunk of meat make a mind?—might be unsolvable.