In the early 1990s, I came to suspect that the quest for a unified theory is religious rather than scientific. Physicists want to show that all thing… - John Horgan

Einstein had drawn attention to nonlocality in 1935 in an effort to show that quantum mechanics must be flawed. ...Einstein proposed a thought experiment—now called the EPR experiment—involving two particles that spring from a common source and fly in opposite directions.
According to the standard model of quantum mechanics, neither particle has a definite position or momentum before it is measured; but by measuring the momentum of one particle, the physicist instantaneously forces the other particle to assume a fixed position... Deriding this effect as "spooky action at a distance," Einstein argued that it violated both common sense and his own theory of special relativity, which prohibits the propagation of effects faster than the speed of light; quantum mechanics must therefore be an incomplete theory. In 1980, however, a group of French physicists carried out a version of the EPR experiment and showed that it did indeed give rise to spooky action. (The reason that the experiment does not violate special relativity is that one cannot exploit nonlocality to transmit information.)

Over the last few decades, physics in the grand mode practiced by Hawking and Rees has become increasingly disconnected from empirical evidence. Proponents of string and multiverse models tout their mathematical elegance, but strings are too small and multiverses too distant to be detected by any plausible experiment.

Can a skeptic avoid self-contradiction... the Popper paradox? And if he doesn’t, if he preaches but fails to practice intellectual doubt and humility, does that negate his work? Not at all. Such paradoxes corroborate the skeptic’s point... the quest for truth is endless, twisty and riddled with pitfalls, into which even sharp-eyed seekers tumble. In our infinite ignorance we are all equal.