[N]othing is too terrible to be true if it is consistent with the laws of nature [...]. - David Pearce

My own sense of how to behave in a simulation has more traditional roots in the theory of perception. I've long believed that each of us lives in an egocentric simulation of the world run by the mind/brain. Since the zombies of each (waking) simulation have sentient real world counterparts, one should treat them as though they were real. Nonetheless as an angst-ridden teenager, my dawning acceptance of an inferential realist theory of perception made me feel as if I'd been condemned to solitary confinement for life. The sense of loneliness was indescribable. Naïve realism is better for one's mental health.

A global transition to a cruelty-free vegan diet won't just help non-human animals. The transition will also help malnourished humans who could benefit from the grain currently fed to factory-farmed animals. For factory-farming is not just cruel; it's energy-inefficient. Let's take just one example. Over the past few decades, millions of Ethiopians have died of "food shortages" while Ethiopia grew grain to sell to the West to feed cattle. Western meat-eating habits prop up the price of grain so that poor people in the developing world can't afford to buy it. In consequence, they starve by the millions.
In my work, I explore futuristic, hi-tech solutions to the problem of suffering. But anybody who seriously wants to reduce human and non-human suffering alike should adopt a cruelty-free vegan lifestyle today.

A few centuries from now, if involuntary suffering still exists in the world, the explanation for its persistence won't be that we've run out of computational resources to phase out its biological signature, but rather that rational agents – for reasons unknown – will have chosen to preserve it.