[N]othing is too terrible to be true if it is consistent with the laws of nature [...]. - David Pearce

The negative utilitarian might reply that this formulation of the problem is misleading. We do not live in a notional world where only a pinprick, minor pains, or even just "mild" suffering exists. In the real world, frightful horrors as well as humdrum malaise occur every day. The intensity of suffering is sometimes so dreadful that its victims are prepared to destroy themselves to bring their torment to an end. Each year, some 800,000 people across the planet kill themselves while in the grip of suicidal despair. Tens of millions of people are severely depressed or suffer chronic neuropathic pain. By way of contrast, the genteel conventions of an ethics seminar in academic philosophy, or the scholarly technicalities of a journal article, simply fail to come to terms with the enormity of what's at stake. To talk of a "pinprick" is to trivialise the NU ethical stance.

More controversially, technology can accelerate the transition from harming to helping free-living sentient beings: mankind's fitfully expanding "circle of compassion". The civilising process needn't be species-specific but instead extend to free-living dwellers in tomorrow's wildlife parks. Every cubic metre of the biosphere will soon be computationally accessible to surveillance, micro-management and control. Fertility regulation via immunocontraception can replace Darwinian ecosystems governed by starvation and predation. Any species of obligate carnivore we choose to preserve can be genetically and behaviourally tweaked into harmlessness. Asphyxiation, disembowelling, and agonies of being eaten alive can pass into the dustbin of history.

The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life.
This project is ambitious but technically feasible. It is also instrumentally rational and ethically mandatory. The metabolic pathways of pain and malaise evolved only because they once served the fitness of our genes. They will be replaced by a different sort of neural architecture. States of sublime well-being are destined to become the genetically pre-programmed norm of mental health. The world's last aversive experience will be a precisely dateable event.
Two hundred years ago, powerful synthetic pain-killers and surgical anesthetics were unknown. The notion that physical pain could be banished from most people's lives would have seemed absurd. Today most of us in the technically advanced nations take its routine absence for granted. The prospect that what we describe as psychological pain, too, could ever be banished is equally counter-intuitive. The feasibility of its abolition turns its deliberate retention into an issue of social policy and ethical choice.