What right have humans to impose our values on members of another race or species? The charge is seductive but misplaced. There is no anthropomorphis… - David Pearce

A lot of people recoil from the word "drugs" - which is understandable given today's noxious street drugs and their uninspiring medical counterparts. Yet even academics and intellectuals in our society typically take the prototypical dumb drug, ethyl alcohol. If it's socially acceptable to take a drug that makes you temporarily happy and stupid, then why not rationally design drugs to make people perpetually happier and smarter? Presumably, in order to limit abuse-potential, one would want any ideal pleasure drug to be akin - in one limited but important sense - to nicotine, where the smoker's brain finely calibrates its optimal level: there is no uncontrolled dose-escalation.

Some days will be sublime. Others will be merely wonderful. But critically, there will be one particular texture ("what it feels like") of consciousness that will be missing from our lives; and that will be the texture of nastiness.

Here the question comes down to an analysis of risk-reward ratios - and our basic ethical values, themselves shaped by our evolutionary past. Lest extension of the new reproductive medicine seem too rashly experimental even to contemplate, it's worth recalling that each act of old-fashioned sexual reproduction is itself an untested genetic experiment, the outcome of random mutations and meiotic shuffling of the genetic deck, and with no happy ending to date. So just who are we to accuse of reckless gambling? As it stands, all of us are genetically predestined to grow old and die; and in the course of a lifetime, the great majority of humans will experience periods of intense psychological distress, for instance loneliness and heartache after an unhappy love affair. Our social primate biology ensures that most of us sometimes experience, to a greater or lesser degree, all manner of nasty states that were genetically adaptive in the ancestral environment e.g. jealousy, resentment, anger, and so forth. Hundreds of millions of people in the world today suffer bouts of depression; others live with chronic anxiety. One might say these phenotypes are part of what it means to be human. Worse, we pass a heritable predisposition to these horrible states on to our children.