The scientific basis for separating neocortical from limbic brain matter rests on solid neuroanatomical, cellular, and empirical grounds. As viewed t… - Thomas Lewis

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The scientific basis for separating neocortical from limbic brain matter rests on solid neuroanatomical, cellular, and empirical grounds. As viewed through the microscope, limbic areas exhibit a far more primitive cellular organization than their neocortical counterparts. Certain radiographic dyes selectively stain limbic structures, thus painting the molecular dissimilarity between the two brains in clean, vivid strokes. One researcher made an antibody that binds to cells of the hippocampus — a limbic component — and found that those same fluorescent markers stuck to all parts of the limbic brain, lighting it up like a biological Christmas tree, without coloring the neocortex at all. Large doses of some medications destroy limbic tissue while leaving the neocortex unscathed, a sharp-shooting feat enabled by evolutionary divergence in the chemical composition of limbic and neocortical cell membranes.