Ronald Coase won the 1991 Nobel Prize in Economics for his theory that larger companies do better because they aggregate assets under one roof and, a… - Salim Ismail

Jerry Michalski notes that in the past, scarcity meant value. That is, without scarcity, you didn't have a business. Now that notion has been upended. Dave Blakely of IDEO thinks about ExOs in the following way: "These new organizations are exponential because they took something scarce and made it abundant." Nokia bought Navteq, trying to buy, own and control scarcity, only to be leapfrogged by Waze, which managed to harness abundance.

History and common sense make clear that you cannot radically transform every part of an organization — and accelerate the underlying clock of that enterprise to hyper-speed — without fundamentally changing the nature of that organization.

One exemplar of that pending disruption is teenager Jack Andraka, who at the age of fourteen single-handedly developed an early-stage detection test for pancreatic cancer that costs just three cents. His approach (awaiting peer review) is 26,000 times cheaper, 400 times more sensitive, and 126 times faster than today's diagnostics. Big Pharma has no idea how to deal with Jack, who is one of many wunderkinds emerging globally, all of them with the potential to disrupt great companies and long-established industries. The Jacks of the world bring exponential