"What is human memory?" Manning asked. He gazed at the air as he spoke, as if lecturing an invisible audience - as perhaps he was. "It certainly is not a passive recording mechanism, like a digital disc or a tape. It is more like a story-telling machine. Sensory information is broken down into shards of perception, which are broken down again to be stored as memory fragments. And at night, as the body rests, these fragments are brought out from storage, reassembled and replayed. Each run-through etches them deeper into the brain's neural structure. And each time a memory is rehearsed or recalled it is elaborated. We may add a little, lose a little, tinker with the logic, fill in sections that have faded, perhaps even conflate disparate events.

"In extreme cases, we refer to this as confabulation. The brain creates and recreates the past, producing, in the end, a version of events that may bear little resemblance to what actually occurred. To first order, I believe it's true to say that everything I remember is false.

The hippocampus is the structure where memory is supposedly controlled. It is the most plastic part of the brain; it is also the part that is assumed to absorb all the damage from repeated insults like the chronic stress we experience daily from small doses of negative feelings — as opposed to the invigorating “good stress” of the tiger popping up occasionally in your living room. You can rationalize all you want; the hippocampus takes the insult of chronic stress seriously, incurring irreversible atrophy. Contrary to popular belief, these small, seemingly harmless stressors do not strengthen you; they can amputate part of your self.

As he describes each mechanism in the brain, he shows how a modern computer could accomplish the same operation, despite the apparent differences. The brain’s analog mechanisms can be simulated through digital ones because digital computation can emulate analog values to any desired degree of precision (and the precision of analog information in the brain is quite low).

His model of an electric eye which records with electric signals message received from outside world, his physical model of memory as a mechanism for storing information justified this being considered a precursor of the modern discipline of cybernetics.

"It's simply part of wider research on a neural expansifier that increases the synaptic pathways in the brain. Aside from repairing traumatic damage and reversing the effects of dementia, it can potentially make dumb people smart."
"I'm trying hard, but I'm not sure I can think of a more useful invention."

With downtime, the neurons made their way from the gateway of memory to the rest of the brain, where long-term memory is stored. The rats were able to record memories of their experiences, which is the basis for learning.

Rather than plug a piece of hardware into our gray matter, how much more elegant to extract some brain cells, plop them into a Petri dish, and graft on various sorts of gelatinous computing goo. Slug it all back into the skull and watch it run on blood sugar, the way a human brain's supposed to.

I collaborated on a brain imaging study in 2010, and the overwhelming conclusion we reached is that the neural patterns were very similar for true and false memories. We are a long way away from being able to look at somebody's brain activity and reliably classify an authentic memory versus one that arose through some other process.

With the arrival of electric technology, man has extended, or set outside himself, a live model of the central nervous system itself. To the degree that this is so, it is a development that suggests a desperate suicidal autoamputation, as if the central nervous system could no longer depend on the physical organs to be protective buffers against the slings and arrows of outrageous mechanism.

How does... representation by simulation work? ...If you are a brain and you want to understand sound, you have to model it. ...Neurons do not want to do 20 Khz. That's way too fast for them. They like something like 20 Hz. So... you need to make a [which] measures the amount of energy at different frequencies. ...This ...in our ears ...transforms energy of sound at different frequency intervals into energy measurements... This is something that the brain can model. ...[A] neurosimulator tries to recreate these patterns. If it can predict the next input from the cochlea, then it understands the sound.

Amid great anticipation, Giacomo slowly lowered the electrode into the callosum. As is commonly done in neurophysiology, the recording system was hooked up to a loudspeaker so that the rat-tat-tat of the neurons firing could be heard. We were ready to hear the Morse code of the brain.
Then it happened. The electrode pierced the callosum. Instead of the rat-tat-tat we expected, the loudspeaker boomed with the excruciatingly clear voice of Ringo Starr singing, “We all live in a yellow submarine, a yellow submarine, a yellow submarine.” Giacomo looked up from the cat and calmly said, “Now that is what I call high-order information.” Some kind of electronic ground loop had been closed, and we were picking up the local radio station. We all laughed, though we knew this brain code thing was going to be a long haul.

Might it be possible at some future time, when neurophysiology has advanced substantially, to reconstruct the memories or insight of someone long dead?...It would be the ultimate breach of privacy.

Instead of reality being passively recorded by the brain, it is actively constructed by it.

that the key is not the stuff out of which brains are made, but the patterns that can come to exist inside the stuff of a brain.