Matter is actually distributed very unevenly... conglomerated into stars and galactic systems. The average density is the density that we should get … - Willem de Sitter

We know by actual observation only a comparatively small part of the whole universe. I will call this "our neighborhood." Even within the confines of this province our knowledge decreases very rapidly as we get away from our own particular position in space and time. It is only within the solar system that our empirical knowledge extends to the second order of small quantities (and that only for g₄₄ and not for the other g_αβ), the first order corresponding to about 10^-8. How the g_αβ outside our neighborhood are, we do not know, and how they are at infinity of space or time we shall never know. Infinity is not a physical but a mathematical concept, introduced to make our equations more symmetrical and elegant. From the physical point of view everything that is outside our neighborhood is pure extrapolation, and we are entirely free to make this extrapolation as we please to suit our philosophical or aesthetical predilections—or prejudices. It is true that some of these prejudices are so deeply rooted that we can hardly avoid believing them to be above any possible suspicion of doubt, but this belief is not founded on any physical basis. One of these convictions, on which extrapolation is naturally based, is that the particular part of the universe where we happen to be, is in no way exceptional or privileged; in other words, that the universe, when considered on a large enough scale, is isotropic and homogeneous.

Gravitation is entirely independent of everything that influences other natural phenomena. It is not subject to absorption or refraction, no velocity of propagation has been observed. You can do whatever you please with a body, you can electrify or magnetise it, you can heat it, melt or evaporate it, decompose it chemically, its behaviour with respect to gravitation is not affected. Gravitation acts on all bodies in the same way, everywhere and always we find it in the same rigorous and simple form, which frustrates all our attempts to penetrate into its internal mechanism.

It is easy to compute the density of a static universe of a radius of two thousand million lightyears, and it comes out only very little larger than the observed density. The actual universe is thus very far from empty, it is, on the contrary, nearly full.