you might think that treatments like group therapy after breast cancer would now be standard. Guess again. Affiliation is not a drug or an operation,… - Thomas Lewis

The scientific basis for separating neocortical from limbic brain matter rests on solid neuroanatomical, cellular, and empirical grounds. As viewed through the microscope, limbic areas exhibit a far more primitive cellular organization than their neocortical counterparts. Certain radiographic dyes selectively stain limbic structures, thus painting the molecular dissimilarity between the two brains in clean, vivid strokes. One researcher made an antibody that binds to cells of the hippocampus — a limbic component — and found that those same fluorescent markers stuck to all parts of the limbic brain, lighting it up like a biological Christmas tree, without coloring the neocortex at all. Large doses of some medications destroy limbic tissue while leaving the neocortex unscathed, a sharp-shooting feat enabled by evolutionary divergence in the chemical composition of limbic and neocortical cell membranes.

a mood is a state of enhanced readiness to experience a certain emotion. Where an emotion is a single note, clearly struck, hanging for a moment in the still air, a mood is the extended, nearly inaudible echo that follows. Consciousness registers a fading level of activation in the emotion circuits faintly or not at all. And so the provocative events of the day may leave us with emotional responsiveness waiting beneath our notice. If a man spills coffee on himself, his annoyance is relatively short-lived — on the order of minutes. After the conscious feeling is gone, residual activity in the anger circuits lingers. He will pass into an irritable mood — a quickness to anger, the only reflection of the waning activity in those circuits.

If the attachment fabric of a civilization frays, if people cannot get from their relationships the emotional regulation that those bonds were designed to furnish, they will commandeer whatever means of limbic modulation they can lay hands on. Their hungering brains will seek satisfaction from a variety of ineffectual substitutes — alcohol, heroin, cocaine, and their cousins.