Stanford psychologist Laura Carstensen, to name one such example, used an fMRI scanner to study the brain behavior of subjects presented with both positive and negative imagery. She found that for young people, their amygdala (a center of emotion) fired with activity at both types of imagery. When she instead scanned the elderly, the amygdala fired only for the positive images. Carstensen hypothesizes that the elderly subjects had trained the prefrontal cortex to inhibit the amygdala in the presence of negative stimuli. These elderly subjects were not happier because their life circumstances were better than those of the young subjects; they were instead happier because they had rewired their brains to ignore the negative and savor the positive. By skillfully managing their attention, they improved their world without changing anything concrete about it.

Another benefit of a sender filter is that it resets expectations. The most crucial line in my description is the following: “I’ll only respond to those proposals that are a good match for my schedule and interests.” This seems minor, but it makes a substantial difference in how my correspondents think about their messages to me. The default social convention surrounding e-mail is that unless you’re famous, if someone sends you something, you owe him or her a response. For most, therefore, an inbox full of messages generates a major sense of obligation. By instead resetting your correspondents’ expectations to the reality that you’ll probably not respond, the experience is transformed. The inbox is now a collection of opportunities that you can glance at when you have the free time — seeking out those that make sense for you to engage. But the pile of unread messages no longer generates a sense of obligation. You could, if you wanted to, ignore them all, and nothing bad would happen. Psychologically, this can be freeing.

Breaking news, for example, is almost always much lower quality than the reporting that’s possible once an event has occurred and journalists have had time to process it. A well-known journalist recently told me that following a breaking story on Twitter gives him the sense that he’s receiving lots of information, but that in his experience, waiting until the next morning to read the article about the story in the Washington Post almost always leaves him more informed. Unless you’re a breaking news reporter, it’s usually counterproductive to expose yourself to the fire hose of incomplete, redundant, and often contradictory information that spews through the internet in response to noteworthy events.

Face-to-face conversation is the most human — and humanizing — thing we do.24 Fully present to one another, we learn to listen. It’s where we develop the capacity for empathy. It’s where we experience the joy of being heard, of being understood.

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What ended up mattering, however, was instead the obsessive efforts of an eccentric creative talent who spent over three years nurturing a vision, coming at it again and again in an attempt to create something special.

Think Small, Act Big.” It’s in this understanding of career capital and its role in mission that we get our explanation for this title. Advancing to the cutting edge in a field is an act of “small” thinking, requiring you to focus on a narrow collection of subjects for a potentially long time. Once you get to the cutting edge, however, and discover a mission in the adjacent possible, you must go after it with zeal: a “big” action.